JH-VIII-157-02 is a potent alk inhibitor. JH-VIII-157-02 can overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation. JH-VIII-157-02 is a structural analogue of alectinib that is potent against the G1202R mutant as well as a variety of other frequently observed mutants. In addition, JH-VIII-157-02 is capable of penetrating the CNS of mice following oral dosing.
MedKoo Cat#: 407894
Name: JH-VIII-157-02
CAS#: 1639422-97-1
Chemical Formula: C28H27N5O2
Exact Mass: 465.2165
Molecular Weight: 465.56
Elemental Analysis: C, 72.24; H, 5.85; N, 15.04; O, 6.87
The following data is based on the product molecular weight 465.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
