MedKoo Cat#: 562678 | Name: TC-E 5002
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor.

Chemical Structure

TC-E 5002
TC-E 5002
CAS#1453071-47-0

Theoretical Analysis

MedKoo Cat#: 562678

Name: TC-E 5002

CAS#: 1453071-47-0

Chemical Formula: C15H27NO4

Exact Mass: 285.1940

Molecular Weight: 285.38

Elemental Analysis: C, 63.13; H, 9.54; N, 4.91; O, 22.42

Price and Availability

Size Price Availability Quantity
5mg USD 400.00
10mg USD 600.00
50mg USD 1,350.00
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Related CAS #
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Synonym
TC-E 5002; TC E 5002; TCE 5002; TCE-5002; TCE5002; TC-E-5002;
IUPAC/Chemical Name
3-(9-cyclopropyl-N-hydroxynonanamido)propanoic acid
InChi Key
NEHSERYKENINRH-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H27NO4/c17-14(16(20)12-11-15(18)19)8-6-4-2-1-3-5-7-13-9-10-13/h13,20H,1-12H2,(H,18,19)
SMILES Code
O=C(N(O)CCC(O)=O)CCCCCCCCC1CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 285.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Lee KH, Kim BC, Jeong SH, Jeong CW, Ku JH, Kim HH, Kwak C. Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in Bladder Cancer Cells. Int J Mol Sci. 2020 Aug 6;21(16):5658. doi: 10.3390/ijms21165658. PMID: 32781788; PMCID: PMC7460860. Lee KH, Hong S, Kang M, Jeong CW, Ku JH, Kim HH, Kwak C. Histone demethylase KDM7A controls androgen receptor activity and tumor growth in prostate cancer. Int J Cancer. 2018 Dec 1;143(11):2849-2861. doi: 10.1002/ijc.31843. Epub 2018 Oct 9. PMID: 30183076.