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MedKoo Cat#: 571559 | Name: Betamethasone acibutate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby's lungs, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others.

Chemical Structure

Betamethasone acibutate
Betamethasone acibutate
CAS#5534-05-4 (acibutate)

Theoretical Analysis

MedKoo Cat#: 571559

Name: Betamethasone acibutate

CAS#: 5534-05-4 (acibutate)

Chemical Formula: C28H37FO7

Exact Mass: 504.2523

Molecular Weight: 504.60

Elemental Analysis: C, 66.65; H, 7.39; F, 3.77; O, 22.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
378-44-9 (free acid) 5534-05-4 (acibutate) 987-24-6 (acetate) 5593-20-4 (dipropionate) 151-73-5 (sodium phosphate) 2152-44-5 (valerate) 22298-29-9 (benzoate)
Synonym
Betamethasone acibutate; NSC 39470; NSC-39470; Sch 4831; Sch-4831; Sch4831.
IUPAC/Chemical Name
9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate 17-isobutyrate
InChi Key
KGNVBESWWSSQAN-QEVRMTOFSA-N
InChi Code
InChI=1S/C28H37FO7/c1-15(2)24(34)36-28(23(33)14-35-17(4)30)16(3)11-21-20-8-7-18-12-19(31)9-10-25(18,5)27(20,29)22(32)13-26(21,28)6/h9-10,12,15-16,20-22,32H,7-8,11,13-14H2,1-6H3/t16-,20-,21-,22-,25-,26-,27-,28-/m0/s1
SMILES Code
C[C@@]12[C@](C(COC(C)=O)=O)(OC(C(C)C)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 504.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kemp MW, Saito M, Usuda H, Watanabe S, Sato S, Hanita T, Kumagai Y, Molloy TJ, Clarke M, Eddershaw PJ, Musk GC, Schmidt A, Ireland D, Furfaro L, Payne MS, Newnham JP, Jobe AH. The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: Evidence from a sheep model of pregnancy. Am J Obstet Gynecol. 2018 May 9. pii: S0002-9378(18)30399-5. doi: 10.1016/j.ajog.2018.05.007. [Epub ahead of print] PubMed PMID: 29758177. 2: Moreira FX, Silva R, André MB, de Pinho PG, Bastos ML, Ruivo J, Ruivo P, Carmo H. Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 4;1089:33-42. doi: 10.1016/j.jchromb.2018.05.004. [Epub ahead of print] PubMed PMID: 29753212. 3: Melo DF, Dutra TBS, Baggieri VMAC, Tortelly VD. Intralesional betamethasone as a therapeutic option for alopecia areata. An Bras Dermatol. 2018 Mar;93(2):311-312. doi: 10.1590/abd1806-4841.20187423. PubMed PMID: 29723356; PubMed Central PMCID: PMC5916422. 4: Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018 Mar 8;8(8):2189-2201. doi: 10.7150/thno.22800. eCollection 2018. PubMed PMID: 29721072; PubMed Central PMCID: PMC5928880. 5: Giaccone V, Macaluso A, Cammilleri G, Vella A, Ferrantelli V. Corticosteroids in liver and urine in Sicilian cattle by a LC-MS/MS Method. Food Addit Contam Part B Surveill. 2018 May 2. doi: 10.1080/19393210.2018.1470578. [Epub ahead of print] PubMed PMID: 29716443. 6: Lee M, Yum MS, Woo DC, Shim WH, Ko TS, Velíšek L. In Vivo Multimodal Magnetic Resonance Imaging Changes After N-Methyl-d-Aspartate-Triggered Spasms in Infant Rats. Front Neurol. 2018 Apr 16;9:248. doi: 10.3389/fneur.2018.00248. eCollection 2018. PubMed PMID: 29713308; PubMed Central PMCID: PMC5911983. 7: Moattari M, Kouchesfehani H, Kaka G, Sadraie H, Naghdi M. Study of transected sciatic nerve repair by biodegradable membrane and betamethasone in adult albino wistar rats. Turk Neurosurg. 2017 Jun 9. doi: 10.5137/1019-5149.JTN.20047-17.1. [Epub ahead of print] PubMed PMID: 29708578. 8: Sasaki T, Ide T, Toda I, Kato N. Amnwiotic Membrane Transplantation as a Treatment for Sterile Infiltration and Corneal Melting after Corneal Crosslinking for Keratoconus. Case Rep Ophthalmol. 2018 Mar 2;9(1):185-189. doi: 10.1159/000487074. eCollection 2018 Jan-Apr. PubMed PMID: 29681834; PubMed Central PMCID: PMC5903102. 9: Schlieckau F, Schulz D, Fill Malfertheiner S, Entleutner K, Seelbach-Goebel B, Ernst W. A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice. Am J Reprod Immunol. 2018 Apr 19:e12859. doi: 10.1111/aji.12859. [Epub ahead of print] PubMed PMID: 29672989. 10: Takahashi K, Asano T, Higashiyama Y, Koyano S, Doi H, Takeuchi H, Tanaka F. Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica. Mult Scler. 2018 Apr 1:1352458518763099. doi: 10.1177/1352458518763099. [Epub ahead of print] PubMed PMID: 29671689. 11: Rittenschober-Böhm J, Rodger J, Jobe AH, Kallapur SG, Doherty DA, Kramer BW, Payne MS, Archer M, Rittenschober C, Newnham JP, Miura Y, Berger A, Matthews SG, Kemp MW. Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep. Neonatology. 2018 Apr 17;114(1):62-68. doi: 10.1159/000487914. [Epub ahead of print] PubMed PMID: 29669335. 12: Cole LK, Rajala-Schultz PJ, Lorch G. Conductive hearing loss in four dogs associated with the use of ointment-based otic medications. Vet Dermatol. 2018 Apr 17. doi: 10.1111/vde.12542. [Epub ahead of print] PubMed PMID: 29664150. 13: Kitahata S, Hirami Y, Takagi S, Kime C, Fujihara M, Kurimoto Y, Takahashi M. Efficacy of additional topical betamethasone in persistent cystoid macular oedema after carbonic anhydrase inhibitor treatments in retinitis pigmentosa. BMJ Open Ophthalmol. 2018 Jan 28;3(1):e000107. doi: 10.1136/bmjophth-2017-000107. eCollection 2018. PubMed PMID: 29657976; PubMed Central PMCID: PMC5895969. 14: Sidgiddi S, Pakunlu RI, Allenby K. Efficacy, Safety, and Potency of Betamethasone Dipropionate Spray 0.05%: A Treatment for Adults with Mild-to-moderate Plaque Psoriasis. J Clin Aesthet Dermatol. 2018 Apr;11(4):14-22. Epub 2018 Apr 1. PubMed PMID: 29657667; PubMed Central PMCID: PMC5891082. 15: Svendsen MT, Andersen F, Andersen KH, Pottegård A, Johannessen H, Möller S, August B, Feldman SR, Andersen KE. An App Supporting Psoriasis Patients Improves Adherence to Topical Treatment: A randomised controlled trial. Br J Dermatol. 2018 Apr 14. doi: 10.1111/bjd.16667. [Epub ahead of print] PubMed PMID: 29654699. 16: Iacobaş DA, Chachua T, Iacobaş S, Benson MJ, Borges K, Velíšková J, Velíšek L. ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms. Sci Rep. 2018 Apr 10;8(1):5722. doi: 10.1038/s41598-018-24013-x. PubMed PMID: 29636502; PubMed Central PMCID: PMC5893534. 17: Sizílio RH, Galvão JG, Trindade GGG, Pina LTS, Andrade LN, Gonsalves JKMC, Lira AAM, Chaud MV, Alves TFR, Arguelho MLPM, Nunes RS. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018 Jun 15;190:339-345. doi: 10.1016/j.carbpol.2018.02.079. Epub 2018 Mar 6. PubMed PMID: 29628256. 18: Mose KF, Andersen F, Røpke MA, Skov L, Friedmann PS, Andersen KE. Anti-inflammatory potency testing of topical corticosteroids and calcineurin inhibitors in human volunteers sensitized to diphenylcyclopropenone. Br J Clin Pharmacol. 2018 Apr 1. doi: 10.1111/bcp.13596. [Epub ahead of print] PubMed PMID: 29607554. 19: Shields CW 4th, White JP, Osta EG, Patel J, Rajkumar S, Kirby N, Therrien JP, Zauscher S. Encapsulation and controlled release of retinol from silicone particles for topical delivery. J Control Release. 2018 May 28;278:37-48. doi: 10.1016/j.jconrel.2018.03.023. Epub 2018 Mar 28. PubMed PMID: 29604311. 20: Simeoni M, Di Vilio R, Leonardi G, Bologna S, Cardone A, Cerantonio A, Sculco D, Chiarella G, Fuiano G. [Case of sialadenitis by iodinated contrast medium in a dialysis patient]. G Ital Nefrol. 2018 Mar;35(2). pii: 2018-vol2. Italian. PubMed PMID: 29582961.