Saccharin sodium | CAS# 128-44-9 | non-nutritive sweetener

MedKoo Cat#: 581226 | Name: Saccharin sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Saccharin sodium is a type of artificial or nonnutritive sweetener. It is 200 to 700 times sweeter than sucrose but has a bitter aftertaste. Saccharin and its salts do not occur naturally. Saccharin sodium is used in the production of various foods and pharmaceutical products including soft drinks, candy, biscuits, jams, chewing gum, tinned fruit, medicine and toothpaste.

Chemical Structure

Saccharin sodium

CAS#128-44-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 581226

Name: Saccharin sodium

CAS#: 128-44-9 (sodium)

Chemical Formula: C7H4NNaO3S

Exact Mass: 0.0000

Molecular Weight: 205.16

Elemental Analysis: C, 40.98; H, 1.97; N, 6.83; Na, 11.21; O, 23.39; S, 15.63

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Related CAS #

82385-42-0 (sodium salt hydrate) 128-44-9 (sodium) 482333-74-4 (1-methylimidazole)

Synonym

Saccharin sodium; CCRIS 706; Saccharin, sodium

IUPAC/Chemical Name

1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, Saccharin, sodium salt; Saccharinnatrium; Soluble gluside; Sweeta; Willosetten;

InChi Key

WINXNKPZLFISPD-UHFFFAOYSA-M

InChi Code

InChI=1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1

SMILES Code

O=C(C1=C2C=CC=C1)[N-]S2(=O)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Saccharin sodium is a sweetening and flavoring agent.

In vitro activity:

The results from this study suggest that saccharin enhances neurite extension by promoting microtubule organization. Saccharin increased the number of N1E-115 cells and total neurite length and longest neurite length in each cell. Saccharin also had a similar effect on NGF-treated PC12 cells. Saccharin increased the amount of the microtubules reconstructed after treatment with nocodazole. Reference: Life Sci. 2013 Nov 6;93(20):732-41. https://pubmed.ncbi.nlm.nih.gov/24095948/

In vivo activity:

This study concluded that maternal consumption of sodium saccharin during pregnancy and lactation programmed alterations in the reproductive parameters of male offspring, thus influencing spermatogenesis. There were decreases in androgen receptor and PCNA expression and quantification, tubular diameter, and luminal volume, sperm count and transit, estradiol concentration. There were also increases in epithelial and interstitial relative volumes. Reference: Biol Reprod. 2023 Jan 14;108(1):98-106. https://pubmed.ncbi.nlm.nih.gov/36219170/

Preparing Stock Solutions

The following data is based on the product molecular weight 205.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Kim HL, Ha AW, Kim WK. Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism. Nutr Res Pract. 2020 Apr;14(2):109-116. doi: 10.4162/nrp.2020.14.2.109. Epub 2020 Jan 21. PMID: 32256985; PMCID: PMC7075742. 2. Yamashita H, Muroi Y, Ishii T. Saccharin enhances neurite extension by regulating organization of the microtubules. Life Sci. 2013 Nov 6;93(20):732-41. doi: 10.1016/j.lfs.2013.09.023. Epub 2013 Oct 3. PMID: 24095948. 3. Godoi AR, Fioravante VC, Santos BM, Martinez FE, Pinheiro PFF. Maternal exposure of rats to sodium saccharin during gestation and lactation on male offspring. Biol Reprod. 2023 Jan 14;108(1):98-106. doi: 10.1093/biolre/ioac190. PMID: 36219170. 4. Aoyama K, Nagano A. Effects of Saccharin Consumption on Operant Responding for Sugar Reward and Incubation of Sugar Craving in Rats. Foods. 2020 Dec 8;9(12):1823. doi: 10.3390/foods9121823. PMID: 33302497; PMCID: PMC7763677.

In vitro protocol:

In vivo protocol:

1. Godoi AR, Fioravante VC, Santos BM, Martinez FE, Pinheiro PFF. Maternal exposure of rats to sodium saccharin during gestation and lactation on male offspring. Biol Reprod. 2023 Jan 14;108(1):98-106. doi: 10.1093/biolre/ioac190. PMID: 36219170. 2. Aoyama K, Nagano A. Effects of Saccharin Consumption on Operant Responding for Sugar Reward and Incubation of Sugar Craving in Rats. Foods. 2020 Dec 8;9(12):1823. doi: 10.3390/foods9121823. PMID: 33302497; PMCID: PMC7763677.

1: Zhang X, Lv J, Hui J, Wu A, Zhao L, Feng L, Deng L, Yu M, Liu F, Yao J, Lei X. Dietary saccharin sodium supplementation improves the production performance of dairy goats without residue in milk in summer. Anim Nutr. 2024 Jun 8;18:166-176. doi: 10.1016/j.aninu.2024.04.018. PMID: 39263440; PMCID: PMC11389551. 2: Lei C, Zhang S, Liu WX, Ye ML, Zhao YG. Fast Determination of Eleven Food Additives in River Water Using C18 Functionalized Magnetic Organic Polymer Nanocomposite Followed by High-Performance Liquid Chromatography. Molecules. 2024 Aug 2;29(15):3675. doi: 10.3390/molecules29153675. PMID: 39125079; PMCID: PMC11314223. 3: Magdy N, Abdelkader NF, Zaki HF, Kamel AS. Potential exacerbation of polycystic ovary syndrome by saccharin sodium Via taste receptors in a letrozole rat model. Food Chem Toxicol. 2024 Sep;191:114874. doi: 10.1016/j.fct.2024.114874. Epub 2024 Jul 19. PMID: 39032681. 4: Yang F, Wang P, Huang Q, Luo J, Hu R, Huang Q, Mao C, Yang L, Liang G, Li Y, Chen X. Saccharin Sodium Coupling Fluorinated Solvent Enabled Stable Interface for High-Voltage Li-Metal Batteries. Small. 2024 Aug;20(32):e2311961. doi: 10.1002/smll.202311961. Epub 2024 Mar 10. PMID: 38461546. 5: Wong SW, Chew SP, Abdul Aziz SA, Mohamed Shah N. Exposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia. Drug Dev Ind Pharm. 2024 Mar 22:1-9. doi: 10.1080/03639045.2024.2327462. Epub ahead of print. PMID: 38459761. 6: Jiang L, Yu Z, Zhao Y, Yin D. Obesogenic potentials of environmental artificial sweeteners with disturbances on both lipid metabolism and neural responses. Sci Total Environ. 2024 Apr 1;919:170755. doi: 10.1016/j.scitotenv.2024.170755. Epub 2024 Feb 9. PMID: 38340820. 7: Cheng S, Wang S, Zheng M, Jin Y, Li J, Zhang M, Li XL, Min JZ. Simultaneous analysis of natural and artificial sweeteners in sugar-free drinks and urine samples by column-switching UHPLC-charged aerosol detection method. J Chromatogr A. 2024 Jan 4;1713:464533. doi: 10.1016/j.chroma.2023.464533. Epub 2023 Nov 28. PMID: 38041977. 8: Ashour ES, Hegazy MA, Al-Alamein AMA, El-Sayed GM, Ghoniem NS. Green chromatographic methods for determination of co-formulated lidocaine hydrochloride and miconazole nitrate along with an endocrine disruptor preservative and potential impurity. BMC Chem. 2023 Nov 8;17(1):151. doi: 10.1186/s13065-023-01065-3. PMID: 37941018; PMCID: PMC10633899. 9: Li X, Feng Y, Wang X, Chen H, Qiu L, Yu Y. Advanced degradation of refractory organic compounds in electroplating wastewater by an in-situ electro-catalytic biological coupling reactor: Removal performance, microbial community and possible mechanism. Sci Total Environ. 2023 Dec 20;905:167299. doi: 10.1016/j.scitotenv.2023.167299. Epub 2023 Sep 22. PMID: 37742966. 10: Wang W, Mu Q, Feng X, Liu W, Xu H, Chen X, Shi F, Gong T. Sweet Taste Receptor T1R3 Expressed in Leydig Cells Is Closely Related to Homeostasis of the Steroid Hormone Metabolism Profile. J Agric Food Chem. 2023 May 24;71(20):7791-7802. doi: 10.1021/acs.jafc.3c01110. Epub 2023 May 15. PMID: 37186581. 11: Kibriya S, Srinivasan I, Setty JV, Anu S, Khan BS. Characterization of Cocoa Bean Husk Extract Particles and its Comparison as a Mouthrinse with Different Vehicles in Children aged 7-12 Years. Int J Clin Pediatr Dent. 2023 Jan- Feb;16(1):54-59. doi: 10.5005/jp-journals-10005-2494. PMID: 37020779; PMCID: PMC10067998. 12: He C, Zhang Z, Han J, Gong C, Zhang J, Wang L, He P, Shan Y, Zhang X. Advanced treatment of high-salinity wastewater by catalytic ozonation with pilot- and full-scale systems and the effects of Cu2+ in original wastewater on catalyst activity. Chemosphere. 2023 Jan;311(Pt 1):136971. doi: 10.1016/j.chemosphere.2022.136971. Epub 2022 Oct 26. PMID: 36309063. 13: Zhang X, Gu J, Zhao C, Hu Y, Zhang B, Wang J, Lv H, Ji X, Wang S. Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice. J Agric Food Chem. 2022 Jan 12;70(1):171-183. doi: 10.1021/acs.jafc.1c06788. Epub 2021 Dec 28. PMID: 34962394. 14: Shen T, Li J. Drinking Non-nutritive Sweetness Solution of Sodium Saccharin or Rebaudioside a for Guinea Pigs: Influence on Histologic Change and Expression of Sweet Taste Receptors in Testis and Epididymis. Front Nutr. 2021 Aug 5;8:720889. doi: 10.3389/fnut.2021.720889. PMID: 34422887; PMCID: PMC8375269. 15: Khan E, Farooqi J, Shafaq H, Khushik KU, Raza SS, Khan S, Rafiq Z, Ahmed B, Chisti S, Imtiaz K, Zafar H, Zafar A. Comparative analysis of N95 respirators fit testing with commercially available and in house reagent. Infect Prev Pract. 2021 Sep;3(3):100116. doi: 10.1016/j.infpip.2021.100116. Epub 2021 Jan 15. PMID: 34316582; PMCID: PMC7837038. 16: Osabutey AF, Kim AY, Seo BY, Mai LX, Koh YH. Alteration of unfolded protein responses and autophagy signaling represented the molecular basis underlying saccharin toxicity to Drosophila (Diptera: Drosophilidae). Arch Insect Biochem Physiol. 2021 Aug;107(4):e21826. doi: 10.1002/arch.21826. Epub 2021 Jul 1. PMID: 34212404. 17: Li J, Zhu S, Lv Z, Dai H, Wang Z, Wei Q, Hamdard E, Mustafa S, Shi F, Fu Y. Drinking Water with Saccharin Sodium Alters the Microbiota-Gut-Hypothalamus Axis in Guinea Pig. Animals (Basel). 2021 Jun 23;11(7):1875. doi: 10.3390/ani11071875. PMID: 34201842; PMCID: PMC8300211. 18: Saito J, Nadatani N, Setoguchi M, Nakao M, Kimura H, Sameshima M, Kobayashi K, Matsumoto H, Yoshikawa N, Yokoyama T, Takahashi H, Suenaga M, Watanabe R, Imai K, Obara M, Hashimoto M, Yamamoto K, Fujiwara N, Sakata W, Nagai H, Enokihara T, Katayama S, Takahashi Y, Araki M, Iino K, Akiyama N, Katsu H, Fushimi K, Takeda T, Torimoto M, Kishi R, Mitsuya N, Kihara R, Hasegawa Y, Hamada Y, Kimura T, Wada M, Tanzawa A, Yamatani A. Potentially harmful excipients in neonatal medications: a multicenter nationwide observational study in Japan. J Pharm Health Care Sci. 2021 Jul 1;7(1):23. doi: 10.1186/s40780-021-00208-9. PMID: 34193299; PMCID: PMC8246663. 19: Xi M, Liu Z, Ding J, Cheng W, Jia D, Lin H. Saccharin Anion Acts as a "Traffic Assistant" of Zn2+ to Achieve a Long-Life and Dendritic-Free Zinc Plate Anode. ACS Appl Mater Interfaces. 2021 Jun 30;13(25):29631-29640. doi: 10.1021/acsami.1c06307. Epub 2021 Jun 21. PMID: 34151569. 20: Liu XP, Sun WQ, Liu TX, Liu BB, Chen CP. Fullerenol as a water-soluble MALDI-MS matrix for rapid analysis of small molecules and efficient quantification of saccharin sodium in foods. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jul 15;1178:122819. doi: 10.1016/j.jchromb.2021.122819. Epub 2021 Jun 4. PMID: 34130205.