Pramiverine | CAS#14334-40-8 | cholinolytic

MedKoo Cat#: 584426 | Name: Pramiverine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pramiverine is a long acting cholinolytic proposed for gastrointestinal spasms.

Chemical Structure

Pramiverine

CAS#14334-40-8

Theoretical Analysis

MedKoo Cat#: 584426

Name: Pramiverine

CAS#: 14334-40-8

Chemical Formula: C21H27N

Exact Mass: 293.2143

Molecular Weight: 293.45

Elemental Analysis: C, 85.95; H, 9.27; N, 4.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Pramiverine; EMD 9806; EMD9806; EMD-9806; HSP 2986; HSP2986; HSP-2986

IUPAC/Chemical Name

4,4-Diphenyl-N-isopropylcyclohexylamine

InChi Key

SBEOBYJLAQKTQX-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H27N/c1-17(2)22-20-13-15-21(16-14-20,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,20,22H,13-16H2,1-2H3

SMILES Code

CC(NC1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)CC1)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 293.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Enenkel HJ, Müller-Calgan H, Schorscher E. [On the cholinolytic activity of pramiverine]. Arzneimittelforschung. 1976 Apr;26(4b):690-6. German. PubMed PMID: 821493. 2: Koch E, Eisele W. [Therapeutic results with the combination pramiverine/metamizole in a multicentre trial (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):745-52. German. PubMed PMID: 782472. 3: Morel CJ. [Experimental studies on pramiverine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):699-702. German. PubMed PMID: 989018. 4: Niemann H, Jakob G. [Eosphagomanometric finding in man after intravenous administration of a new cholinolytic (pramiverine), atropine and scopolamine butylbromide]. Arzneimittelforschung. 1976 Apr;26(4b):728-30. German. PubMed PMID: 989022. 5: Steiner K, Garbe A. [Organ distribution of 14C-pramiverine in the rat]. Arzneimittelforschung. 1976 Apr;26(4b):709-16. German. PubMed PMID: 989020. 6: Chieri RA. [Animal experimental study on spasmolytic and analgesic activities of pramiverine, metamizole and their combination (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):696-8. German. PubMed PMID: 989017. 7: Eberstein M, Frohberg H, Hofmann A, Jochmann G, Metallinos A, Schiling B, Weisse G. Toxicological study on pramiverine (author's transl). Arzneimittelforschung. 1976 Apr;26(4b):703-9. German. PubMed PMID: 989019. 8: Du Chêne de Vère F, Costantino E. [Pramiverine/metamizole - a spasmoanalgesic for routine therapy of symptoms in emergency/a clinical trial in patients with biliary colics (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):740-4. German. PubMed PMID: 782471. 9: Romero HE, Fernández AC, Rosales TC. [The effect of the combination pramiverine/metamizole in colic pain (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):738-40. German. PubMed PMID: 989023. 10: Toledo GM. [Clinical trial of a novel spasmolytic, pramiverine, and its influence in colitis (author's transl]. Arzneimittelforschung. 1976 Apr;26(4b):731-2. German. PubMed PMID: 782470. 11: Steiner K, Diekmann HW, Garbe A, Nowak H. [Pharmacokinetics of pramiverine in rats, dogs, and monkeys (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):717-21. German. PubMed PMID: 821494. 12: Diekmann HW, Bühring KU, Garbe A, Nowak H. [Metabolism of pramiverine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):722-6. German. PubMed PMID: 821495. 13: Lo Dico G, Milia S, Gigliotti B, Pes F, Stoppelli I. [The use of pramiverine hydrochloride in the active treatment of labor]. Minerva Ginecol. 1979 Sep;31(9):683-7. Italian. PubMed PMID: 537712. 14: Diekmann HW. [Gaschromatographic determination of pramiverine in body fluids (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):727-8. German. PubMed PMID: 989021. 15: Breda G, Brontesi L, Dal Bianco M. [Cineradiographic study of the mechanism of action of a commonly used antispastic drug on the upper urinary tract: pramiverine]. Chir Ital. 1978 Oct;30(5):629-41. Italian. PubMed PMID: 699236. 16: Klinger J. [Evaluation of the antispasmodic pramiverine as an aid for endoscopic retrograde cholangiography (author's transl)]. Rev Med Chil. 1978 Dec;106(12):1031-33. Spanish. PubMed PMID: 746258. 17: Koch E. [Profile comment on clinical and experimental studies of pramiverine and pramiverine/metamizole (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):686-9. German. PubMed PMID: 782469.