DMAKO-20 is a multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme. DMAKO-20 potently inhibits HCT-15, HCT-116 and K562 cells growth, and shows moderate anti-proliferative activity towards MDA-MB-231, HepG2, PANC, Bel7402 and MGC803 cancer cells, while being nontoxic to the human normal VEC and HSF cells.
MedKoo Cat#: 565386
Name: DMAKO-20
CAS#: NONE
Chemical Formula: C23H32N2O5
Exact Mass: 416.2311
Molecular Weight: 416.52
Elemental Analysis: C, 66.32; H, 7.74; N, 6.73; O, 19.21
The following data is based on the product molecular weight 416.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
