Synonym
SC 8109; SC-8109; SC8109;
IUPAC/Chemical Name
(8R,9S,10R,13S,14R,17R)-13-methyl-1,3',4',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
InChi Key
CXXAIOQMCGJVHT-JNCUIMROSA-N
InChi Code
InChI=1S/C21H28O3/c1-20-9-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(20)7-10-21(20)11-8-19(23)24-21/h12,15-18H,2-11H2,1H3/t15-,16+,17+,18+,20-,21+/m0/s1
SMILES Code
O=C(O1)CC[C@]1(CC[C@@H]2[C@@H]3CCC4=C5)[C@@]2(C)CC[C@@H]3[C@H]4CCC5=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: MOLL HC, KOCZOREK KR. [On the influence of an aldosterone antagonist (SC-8109) on the absorption of sodium from the gastrointestinal tract of rats]. Klin Wochenschr. 1962 Aug 15;40:825-7. German. PubMed PMID: 14475194.
2: TANZ RD. Studies on the inotropic action of aldosterone on isolated cardiac tissue preparations; including the effects of pH, ouabain and SC-8109. J Pharmacol Exp Ther. 1962 Jan;135:71-8. PubMed PMID: 13919589.
3: KISTLER H, FRAWLEY TF. Effects of a spirolactone (SC-8109) in primary mineralocorticoid excess. J Clin Endocrinol Metab. 1960 Aug;20:1158-67. PubMed PMID: 14409470.
4: SINGER B. Effect of aldosterone-antagonist, SC 8109, on the secretion of aldosterone in normal rats. Endocrinology. 1959 Sep;65:512-4. PubMed PMID: 14447060.
5: LUPULESCU A, NICOLESCU-CATARGIA, NEACSUC. Effects of an aldosterone-antagonist (SC-8109) on radio-sodium (Na22) metabolism in rats with hypothalamic lesions. Acta Biol Med Ger. 1961;6:482-90. PubMed PMID: 14467462.
6: WIGGINS RA, HUTCHIN ME, CARBONE JV, DOOLAN PD. Effect of spirolactone SC 8109 on renal function in normal human subjects. Proc Soc Exp Biol Med. 1959 Mar;100(3):625-7. PubMed PMID: 13634231.
7: VANDER AJ, WILDE WS, MALVIN RL. Stop flow analysis of aldosterone and steroidal antagonist SC-8109 on renal tubular sodium transport kinetics. Proc Soc Exp Biol Med. 1960 Mar;103:525-7. PubMed PMID: 13841216.
8: BAILEY RE. Acute effects of corticosteroid mixtures and the 17-spirolactone SC-8109 on sodium, potassium, and water excretion in adrenalectomized, water-loaded rats. Endocrinology. 1960 Dec;67:807-14. PubMed PMID: 13685974.
9: Corvol P, Claire M, Oblin ME, Geering K, Rossier B. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. Review. PubMed PMID: 7029118.
10: Cole DF. REDUCTION IN AQUEOUS HUMOUR FORMATION AS CAUSED BY IODATE, SPIROLACTONE, AND POLYPHLORETIN PHOSPHATE. Br J Ophthalmol. 1962 May;46(5):291-303. PubMed PMID: 18170778; PubMed Central PMCID: PMC510196.
11: McInnes GT, Harrison IR, Shelton JR, Perkins RM. Quantitative comparison of aldosterone antagonists in normal human subjects: prediction of therapeutic potency. Br J Clin Pharmacol. 1981 Nov;12(5):743-7. PubMed PMID: 7332740; PubMed Central PMCID: PMC1401948.
