MedKoo Cat#: 531557 | Name: BMS614
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). BMS614 antagonizes agonist-induced coactivator (CoA) recruitment.

Chemical Structure

BMS614
BMS614
CAS#182135-66-6

Theoretical Analysis

MedKoo Cat#: 531557

Name: BMS614

CAS#: 182135-66-6

Chemical Formula: C29H24N2O3

Exact Mass: 448.1787

Molecular Weight: 448.52

Elemental Analysis: C, 77.66; H, 5.39; N, 6.25; O, 10.70

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
50mg USD 1,250.00 2 Weeks
100mg USD 2,150.00 2 Weeks
1g USD 5,450.00 2 Weeks
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Related CAS #
182135-66-6 253310-42-8
Synonym
BMS614; BMS 614; BMS-614; BMS-195614; BMS195614; BMS 195614
IUPAC/Chemical Name
4-[(5,5-dimethyl-8-quinolin-3-yl6H-naphthalene-2-carbonyl)amino]benzoic acid
InChi Key
WGLMBRZXZDAQHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)
SMILES Code
O=C(O)C1=CC=C(NC(C2=CC=C3C(C)(C)CC=C(C4=CC5=CC=CC=C5N=C4)C3=C2)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Idres N, Benoît G, Flexor MA, Lanotte M, Chabot GG. Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites. Cancer Res. 2001 Jan 15;61(2):700-5. PubMed PMID: 11212271. 2: Vivat V, Zechel C, Wurtz JM, Bourguet W, Kagechika H, Umemiya H, Shudo K, Moras D, Gronemeyer H, Chambon P. A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers. EMBO J. 1997 Sep 15;16(18):5697-709. PubMed PMID: 9312028; PubMed Central PMCID: PMC1170201.