BS2G-d4 Deuterated Crosslinker | 910292-86-3

MedKoo Cat#: 571630 | Name: BS2G-d4 Deuterated Crosslinker

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BS2G-d4, or Bis(Sulfosuccinimidyl) 2,2,4,4-glutarate-d4, is a water soluble and cell membrane impermeable, protein crosslinker containing 4 deuterium atoms to provide a 4 dalton shift by mass spectrometry analysis.

Chemical Structure

BS2G-d4 Deuterated Crosslinker

CAS#910292-86-3 (sodium)

Theoretical Analysis

MedKoo Cat#: 571630

Name: BS2G-d4 Deuterated Crosslinker

CAS#: 910292-86-3 (sodium)

Chemical Formula: C13H8D4N2Na2O14S2

Exact Mass: 533.9776

Molecular Weight: 534.36

Elemental Analysis: C, 29.22; H, 3.02; N, 5.24; Na, 8.60; O, 41.92; S, 12.00

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450.00	2 Weeks
50mg	USD 1,250.00	2 Weeks

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Related CAS #

341520-63-6 (free acid)

Synonym

D4-BS2G, BS2G-d4

IUPAC/Chemical Name

Glutaric acid-2,2,4,4-d4 bis (3-sulfo-N-hydroxysuccinimide ester) disodium salt

InChi Key

JINCQYPCQMBZSX-SNSYAXNKSA-L

InChi Code

InChI=1S/C13H14N2O14S2.2Na/c16-8-4-6(30(22,23)24)12(20)14(8)28-10(18)2-1-3-11(19)29-15-9(17)5-7(13(15)21)31(25,26)27;;/h6-7H,1-5H2,(H,22,23,24)(H,25,26,27);;/q;2*+1/p-2/i2D2,3D2;;

SMILES Code

O=C(ON1C(CC(S(=O)([O-])=O)C1=O)=O)C([2H])([2H])CC([2H])([2H])C(ON2C(CC(S(=O)([O-])=O)C2=O)=O)=O.[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Use heavy BS2G-d4 deuterated crosslinking reagent in combination with the non-deuterated analog BS2G-d0 (BS2G-d0, BS2G) for mass spec studies. Together BS2G-d0 and BS2G-d4 can be used for protein-protein interaction mapping using Liquid Chromatography–Mass Spectrometry (LCMS, LC/MS, LC-MS).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 534.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Haladová K, Mrázek H, Ječmen T, Halada P, Man P, Novák P, Chmelík J, Obšil T, Šulc M. The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3ζ homodimer interface. J Struct Biol. 2012 Jul;179(1):10-7. doi: 10.1016/j.jsb.2012.04.016. Epub 2012 May 2. PubMed PMID: 22580067.