Xorphanol | CAS#77287-89-9

MedKoo Cat#: 341453 | Name: Xorphanol free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Xorphanol, also known as TR-5379 or TR-5379M, is a mixed agonist–antagonist of opioid receptors. Xorphanol acts preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).

Chemical Structure

Xorphanol free base

CAS#77287-89-9 (free base)

Theoretical Analysis

MedKoo Cat#: 341453

Name: Xorphanol free base

CAS#: 77287-89-9 (free base)

Chemical Formula: C23H31NO

Exact Mass: 337.2406

Molecular Weight: 337.51

Elemental Analysis: C, 81.85; H, 9.26; N, 4.15; O, 4.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

77287-89-9 (free base) 77287-90-2 (mesylate) 82935-02-2 (HCl)

Synonym

Xorphanol; TR-5379; TR 5379; TR5379.

IUPAC/Chemical Name

Morphinan-3-ol, 17-(cyclobutylmethyl)-8-methyl-6-methylene-, (8beta)-

InChi Key

AZJPPZHRNFQRRE-LTFXSFKNSA-N

InChi Code

InChI=1S/C23H31NO/c1-15-10-16(2)22-21-11-18-6-7-19(25)12-20(18)23(22,13-15)8-9-24(21)14-17-4-3-5-17/h6-7,12,16-17,21-22,25H,1,3-5,8-11,13-14H2,2H3/t16-,21-,22+,23-/m1/s1

SMILES Code

[H][C@]1([C@]2(C3)C4=CC(O)=CC=C4C[C@H]1N(CC5CCC5)CC2)[C@H](C)CC3=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 337.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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