MedKoo Cat#: 565162 | Name: A-1165901

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A-1165901 is a blocker of the activation of the TRPV1 channel by capsaicin, thereby inducing hypothermia involving tail-skin, vasodilation at thermoneutrality, as well as a decrease body temperature.

Chemical Structure

A-1165901
A-1165901
CAS#1444789-64-3

Theoretical Analysis

MedKoo Cat#: 565162

Name: A-1165901

CAS#: 1444789-64-3

Chemical Formula: C24H26FN3O3

Exact Mass: 423.1958

Molecular Weight: 423.49

Elemental Analysis: C, 68.07; H, 6.19; F, 4.49; N, 9.92; O, 11.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
A1165901; A-1165901; A 1165901
IUPAC/Chemical Name
1-((R)-2,2-Diethyl-6-fluoro-chroman-4-yl)-3-(1-methyl-isoquinolon-5-yl)-urea
InChi Key
XRVJVYHEFSIEJG-HXUWFJFHSA-N
InChi Code
InChI=1S/C24H26FN3O3/c1-4-24(5-2)13-20(18-11-15(25)9-10-21(18)31-24)28-23(30)27-19-8-6-7-16-14(3)26-22(29)12-17(16)19/h6-11,20H,4-5,12-13H2,1-3H3,(H2,27,28,30)/t20-/m1/s1
SMILES Code
O=C(NC1=CC=CC2=C1CC(N=C2C)=O)N[C@@H]3CC(CC)(CC)OC4=C3C=C(F)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garami A, Pakai E, McDonald HA, Reilly RM, Gomtsyan A, Corrigan JJ, Pinter E, Zhu DXD, Lehto SG, Gavva NR, Kym PR, Romanovsky AA. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. doi: 10.1111/apha.13038. Epub 2018 Feb 16. PubMed PMID: 29352512; PubMed Central PMCID: PMC6032921.