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MedKoo Cat#: 341448 | Name: Micronomicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Micronomicin is a biochemical.

Chemical Structure

Micronomicin
Micronomicin
CAS#52093-21-7 (free base)

Theoretical Analysis

MedKoo Cat#: 341448

Name: Micronomicin

CAS#: 52093-21-7 (free base)

Chemical Formula: C20H41N5O7

Exact Mass: 463.3006

Molecular Weight: 463.58

Elemental Analysis: C, 51.82; H, 8.92; N, 15.11; O, 24.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
66803-19-8 (sulfate) 52093-21-7 (free base)
Synonym
Micronomicin ; KW-1062; KW 1062; KW1062; XK-62-2; XK 62-2; XK62-2.
IUPAC/Chemical Name
D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy
InChi Key
DNYGXMICFMACRA-XHEDQWPISA-N
InChi Code
InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1
SMILES Code
CNC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 463.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bi S, Zhou H, Wu J, Sun X. Micronomicin/tobramycin binding with DNA: fluorescence studies using of ethidium bromide as a probe and molecular docking analysis. J Biomol Struct Dyn. 2018 Apr 24:1-13. doi: 10.1080/07391102.2018.1461138. [Epub ahead of print] PubMed PMID: 29685085. 2: Yuan Y, Chopra S, Deng X, Zhang M, Fan X, Hu C, Jin S, Van Schepdael A, Adams E. Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 2013 Jun 21;1295:90-8. doi: 10.1016/j.chroma.2013.04.059. Epub 2013 Apr 27. PubMed PMID: 23683397. 3: Yang LH, Chang Y, Yao SC, Hu CQ. Simultaneous determination of purity and potency of the components of gentamycin using high-performance liquid chromatography. Yao Xue Xue Bao. 2012 Dec;47(12):1660-6. PubMed PMID: 23460973. 4: Liu P, Wen J, Chen Y, Jia X. Femtosecond laser-based mutagenesis strategy for micronomicin production enhancement of Micromonospora sagamiensis ATCC 21826. World J Microbiol Biotechnol. 2013 Jun;29(6):1121-7. doi: 10.1007/s11274-013-1261-0. Epub 2013 Jan 25. PubMed PMID: 23355136. 5: Yuan YZ, Zhao X, Zhang M, Fan XL, Hu CQ, Jin SH, Van Schepdael A, Hoogmartens J, Adams E. Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry. J Pharm Biomed Anal. 2013 Mar 5;75:94-104. doi: 10.1016/j.jpba.2012.11.029. Epub 2012 Nov 27. PubMed PMID: 23261805. 6: Chen Y, Li X, He L, Tang S, Xiao X. Immunoassays for the rapid detection of gentamicin and micronomicin in swine muscle. J AOAC Int. 2010 Jan-Feb;93(1):335-42. PubMed PMID: 20334196. 7: Kamiya K, Kasahara M, Shimizu K. A case of intractable infectious keratitis and subsequent flap necrosis after laser in situ keratomileusis. Clin Ophthalmol. 2009;3:523-5. Epub 2009 Sep 24. PubMed PMID: 19789661; PubMed Central PMCID: PMC2754083. 8: Sunada A, Ueda A, Inoue Y, Ohashi Y, Uno T, Kitagawa K, Hatano H, Shiota H, Asari S. [Comparison of minimum inhibitory concentration and postantibiotic effect of eyedrops on isolates in National Surveillance of Infectious Keratitis in Japan]. Nippon Ganka Gakkai Zasshi. 2006 Dec;110(12):973-83. Japanese. PubMed PMID: 17228760. 9: Zhou MJ, Zhong DF, Sun YM, Liu CX. [Electrospray ion trap mass spectrometry of eight aminoglycoside antibiotics]. Yao Xue Xue Bao. 2004 Oct;39(10):826-30. Chinese. PubMed PMID: 15700825. 10: Fukuda M, Sasaki K. General purpose antimicrobial ophthalmic solutions evaluated using new pharmacokinetic parameter of maximum drug concentration in aqueous. Jpn J Ophthalmol. 2002 Jul-Aug;46(4):384-90. PubMed PMID: 12225816. 11: Fukuda M, Sasaki K. [Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous]. Nippon Ganka Gakkai Zasshi. 2002 Apr;106(4):195-200. Japanese. PubMed PMID: 11979978. 12: Marone P, Monzillo V, Carretto E, Haeusler E, Antoniazzi E. In vitro activity of sagamicin against ocular bacterial isolates. Ophthalmologica. 2002 Mar-Apr;216(2):133-8. PubMed PMID: 11919440. 13: Sunada A, Ikeda Y, Kondo S, Hotta K. Acetylation of aminoglycoside antibiotics with 6'-methylamino group, istamycin B and micronomicin, by a novel aminoglycoside 6'-acetyltransferase of actinomycete origin. J Antibiot (Tokyo). 2000 Dec;53(12):1416-9. PubMed PMID: 11217809. 14: Hotta K, Sunada A, Ikeda Y, Kondo S. Double stage activity in aminoglycoside antibiotics. J Antibiot (Tokyo). 2000 Oct;53(10):1168-74. PubMed PMID: 11132963. 15: Matsukawa S, Suh JH, Hashimoto Y, Kato M, Satoh D, Saito S, Endo K, Saishu T. Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit. Tohoku J Exp Med. 1997 Apr;181(4):471-3. PubMed PMID: 9210254. 16: Ma L, Huang B. [Determination of the content for micronomicin sulfate by ultraviolet spectrophotometric derivatization]. Hunan Yi Ke Da Xue Xue Bao. 1997;22(4):363-5. Chinese. PubMed PMID: 9868100. 17: Uete T, Matsuo K, Uete G. Cross-resistance of clinical isolates of methicillin-resistant Staphylococcus aureus to aminoglycosides and fluoroquinolones. Jpn J Antibiot. 1992 Aug;45(8):943-8. PubMed PMID: 1433900. 18: Mezzatesta ML, Pellegrino MB, D'Amico G, Uva M, Russo G, Nicoletti G. Preliminary results on the antibacterial activity of sagamicin towards microorganisms responsible for ocular pathology. J Chemother. 1989 Jul;1(4 Suppl):191-2. PubMed PMID: 16312363. 19: Inouye S, Hara T, Matsuhashi Y, Kitasato I. Antimicrobial activity of dactimicin in vitro compared with that of dibekacin, netilmicin, sisomicin and micronomicin. Drugs Exp Clin Res. 1989;15(10):455-63. PubMed PMID: 2632214. 20: Suzuki K, Takanashi K. [Study of efficacy and safety of micronomicin administered by intravenous drip infusion in treatment against complicated urinary tract infections]. Jpn J Antibiot. 1987 Jan;40(1):117-35. Japanese. PubMed PMID: 3586325.