Dac 5945 | CAS# 124065-13-0 | xxxx

MedKoo Cat#: 581197 | Name: Dac 5945

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DAC 5945 is a more potent muscarinic antagonist in the airways than in the heart, demonstrating M3/M2 selectivity in vivo.

Chemical Structure

Dac 5945

CAS#124065-13-0

Theoretical Analysis

MedKoo Cat#: 581197

Name: Dac 5945

CAS#: 124065-13-0

Chemical Formula: C19H30ClN3O

Exact Mass: 351.2077

Molecular Weight: 351.92

Elemental Analysis: C, 64.85; H, 8.59; Cl, 10.07; N, 11.94; O, 4.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Dac 5945;

IUPAC/Chemical Name

N-Iminomethyl-N'-((2-hydroxy-2-phenyl-2-cyclohexyl)ethyl)piperazine hcl

InChi Key

ABECNUXOXSXJCR-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H29N3O.ClH/c20-16-22-13-11-21(12-14-22)15-19(23,17-7-3-1-4-8-17)18-9-5-2-6-10-18;/h1,3-4,7-8,16,18,20,23H,2,5-6,9-15H2;1H

SMILES Code

OC(C1CCCCC1)(C2=CC=CC=C2)CN3CCN(C=N)CC3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 351.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Howell RE, Laemont KD, Noronha-Blob L. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196(3):323-6. PubMed PMID: 1893917. 2: Howell RE, Kovalsky MP, Laemont KD. Methoctramine induces nonspecific airway hyperresponsiveness in vivo. Eur J Pharmacol. 1994 Nov 14;265(1-2):67-75. PubMed PMID: 7883031. 3: Roffel AF, Hamstra JJ, Elzinga CR, Zaagsma J. Selectivity profile of some recent muscarinic antagonists in bovine and guinea-pig trachea and heart. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):82-98. PubMed PMID: 7893193.