MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 527837 | Name: Lenperone HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lenperone HCl is a dopamine antagonist; Antipsychotic agent.

Chemical Structure

Lenperone HCl
Lenperone HCl
CAS#24677-86-9

Theoretical Analysis

MedKoo Cat#: 527837

Name: Lenperone HCl

CAS#: 24677-86-9

Chemical Formula: C22H24ClF2NO2

Exact Mass: 407.1464

Molecular Weight: 407.89

Elemental Analysis: C, 64.78; H, 5.93; Cl, 8.69; F, 9.32; N, 3.43; O, 7.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Lenperone HCl
IUPAC/Chemical Name
4-[4-(4-Fluorobenzoyl)piperidin-1-yl]-1-(4-fluorophenyl)butan-1-one hydrochloride
InChi Key
BUPKTBMYUMORNV-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23F2NO2.ClH/c23-19-7-3-16(4-8-19)21(26)2-1-13-25-14-11-18(12-15-25)22(27)17-5-9-20(24)10-6-17;/h3-10,18H,1-2,11-15H2;1H
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 407.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu J, Hu KF, Qu JP, Kang YB. Organopromoted Selectivity-Switchable Synthesis of Polyketones. Org Lett. 2017 Oct 20;19(20):5593-5596. doi: 10.1021/acs.orglett.7b02731. Epub 2017 Oct 5. PubMed PMID: 28981291. 2: Beaver BV. Animal behavior case of the month. Cat with 7-week history of spraying urine and defecating in house. J Am Vet Med Assoc. 1994 Jan 1;204(1):53-4. PubMed PMID: 7907322. 3: Chiou GC, Chen YJ. Improvement of ocular blood flow with dopamine antagonists on ocular-hypertensive rabbit eyes. Zhongguo Yao Li Xue Bao. 1992 Nov;13(6):481-4. PubMed PMID: 1302433. 4: Sato F, Owen M, Matthes R, Sato K, Gisolfi CV. Functional and morphological changes in the eccrine sweat gland with heat acclimation. J Appl Physiol (1985). 1990 Jul;69(1):232-6. PubMed PMID: 2203723. 5: Owen MD, Matthes RD, Gisolfi CV. Effects of CSF ANG II and AVP on sweating in the heat-stressed patas monkey. J Appl Physiol (1985). 1989 Jul;67(1):134-40. PubMed PMID: 2759937. 6: Owen MD, Matthes RD, Gisolfi CV. Effect of cerebrospinal fluid hyperosmolality on sweating in the heat-stressed patas monkey. J Appl Physiol (1985). 1989 Jul;67(1):128-33. PubMed PMID: 2759936. 7: Johnson SE, Zelner A, Sherding RG. Esophageal acid clearance test in healthy dogs. Can J Vet Res. 1989 Apr;53(2):244-7. PubMed PMID: 2713789; PubMed Central PMCID: PMC1255554. 8: Johnson SE, Zelner A, Sherding RG. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. PubMed PMID: 2565757; PubMed Central PMCID: PMC1255555. 9: Kraus KH, Turrentine MA, Jergens AE, Johnson GS. Effect of desmopressin acetate on bleeding times and plasma von Willebrand factor in Doberman pinscher dogs with von Willebrand's disease. Vet Surg. 1989 Mar-Apr;18(2):103-9. PubMed PMID: 2786279. 10: Chiou GC, Li BH, Chiou FY. Effects of dopamine antagonists injected through vortex veins on intraocular pressure. J Ocul Pharmacol. 1989 Winter;5(4):281-91. PubMed PMID: 2576433. 11: Benson GJ, Thurmon JC, Tranquilli WJ, Corbin JE. Intravenous administration of lenperone and glycopyrrolate followed by continuous infusion of sufentanil in dogs: cardiovascular effects. Am J Vet Res. 1987 Sep;48(9):1372-5. PubMed PMID: 2959181. 12: Osman MA, Pinchbeck FM, Cheng LK, Wright GJ. Determination of lenperone in dog plasma by high-performance liquid chromatography. J Chromatogr. 1985 Dec 13;345(2):430-5. PubMed PMID: 2868021. 13: Chiou GC. Treatment of ocular hypertension and glaucoma with dopamine antagonists. Ophthalmic Res. 1984;16(3):129-34. PubMed PMID: 6147806. 14: Hays SE, Poland RE, Rubin RT. Prolactin releasing potencies of antipsychotic and related nonantipsychotic compounds in female rats: relation to clinical potencies. J Pharmacol Exp Ther. 1980 Aug;214(2):362-7. PubMed PMID: 6104725. 15: Aimoto T, Kaida M, Sato M, Sato M, Kimura R, Murata T. Effects of neuroleptic butyrophenones on pituitary-adrenal activity in rats. J Pharmacobiodyn. 1980 Jan;3(1):46-52. PubMed PMID: 6110713. 16: Woggon B, Franke A, Hucker H, Ruether E, Athen D, Angst J, Hippius H. Antipsychotic effects, side effects and effective dosis of the butyrophenone lenperone (AHR 2277). Int Pharmacopsychiatry. 1977;12(2):113-26. PubMed PMID: 561037. 17: Nakra BR, Jones CJ, Majumdar AK, Gaind R. Preliminary evaluation of a new psychotropic drug, lenperone, in the treatment of acute schizophrenia. Curr Med Res Opin. 1977;4(8):529-34. PubMed PMID: 559569. 18: Costall B, Naylor RJ. Dissociation of stereotyped biting responses and oro-bucco-lingual dyskinesias. Eur J Pharmacol. 1976 Apr;36(2):423-9. PubMed PMID: 945168. 19: Fabre LF, Harris RT. Pilot open-label study of lenperone (AHR 2277), a butyrophenone, in anxiety. Curr Ther Res Clin Exp. 1976 Mar;19(3):328-31. PubMed PMID: 817861. 20: Mielke DH, Gallant DM, Kessler C, Roniger JJ. Lenperone: a controlled evaluation in chronic schizophrenic patients. Curr Ther Res Clin Exp. 1975 Nov;18(5):636-40. PubMed PMID: 812640.