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MedKoo Cat#: 527832 | Name: Amperozide HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amperozide HCl is a 5-HT2/D2 antagonist, inhibiting nomifensine-induced hyperlocomotion and human FAAH. Amperozide, a novel 5-HT2A receptor antagonist that releases dopamine from mesolimbic neurons, suppresses alcohol drinking in rats.

Chemical Structure

Amperozide HCl
Amperozide HCl
CAS#75529-73-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 527832

Name: Amperozide HCl

CAS#: 75529-73-6 (HCl)

Chemical Formula: C23H30ClF2N3O

Exact Mass: 0.0000

Molecular Weight: 437.96

Elemental Analysis: C, 63.08; H, 6.90; Cl, 8.09; F, 8.68; N, 9.59; O, 3.65

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
86725-37-3 (also HCl) 75529-73-6 (HCl) 75558-90-6 (free base)
Synonym
Amperozide HCl, Amperozide hydrochloride,
IUPAC/Chemical Name
4-[4,4-Bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide hydrochloride
InChi Key
OEQHKNWFXHBJIT-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H29F2N3O.ClH/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19;/h5-12,22H,2-4,13-17H2,1H3,(H,26,29);1H
SMILES Code
O=C(N1CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)NCC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 437.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nuss AB, Ejendal KF, Doyle TB, Meyer JM, Lang EG, Watts VJ, Hill CA. Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors. PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003515. doi: 10.1371/journal.pntd.0003515. eCollection 2015 Mar. PubMed PMID: 25793586; PubMed Central PMCID: PMC4368516. 2: Vincent F, Nguyen MT, Emerling DE, Kelly MG, Duncton MA. Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6. doi: 10.1016/j.bmcl.2009.09.086. Epub 2009 Sep 30. PubMed PMID: 19850474. 3: Chang PY, Chuang CH, Chen JC, Tung CS. Behavioral and biochemical effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systems. Chin J Physiol. 2008 Apr 30;51(2):106-15. Erratum in: Chin J Physiol. 2008 Jun 30;51(3):196. PubMed PMID: 18666714. 4: McMillen BA, Shank JE, Jordan KB, Williams HL, Basile AS. Effect of DOV 102,677 on the volitional consumption of ethanol by Myers' high ethanol-preferring rat. Alcohol Clin Exp Res. 2007 Nov;31(11):1866-71. Epub 2007 Sep 26. PubMed PMID: 17908267. 5: Overstreet DH, Rezvani AH, Cowen M, Chen F, Lawrence AJ. Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. Addict Biol. 2006 Sep;11(3-4):356-73. Review. PubMed PMID: 16961764. 6: Fredriksson A, Archer T. Functional alteration by NMDA antagonist: effects of L-Dopa, neuroleptics drug and postnatal administration. Amino Acids. 2002;23(1-3):111-32. PubMed PMID: 12373526. 7: Rademacher DJ, Schuyler AL, Kruschel CK, Steinpreis RE. Effects of cocaine and putative atypical antipsychotics on rat social behavior: an ethopharmacological study. Pharmacol Biochem Behav. 2002 Nov;73(4):769-78. PubMed PMID: 12213521. 8: Rademacher DJ, Anderson AP, Steinpreis RE. Acute effects of amperozide and paroxetine on social cohesion in male conspecifics. Brain Res Bull. 2002 Jun;58(2):187-91. PubMed PMID: 12127016. 9: Rauser L, Savage JE, Meltzer HY, Roth BL. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. J Pharmacol Exp Ther. 2001 Oct;299(1):83-9. PubMed PMID: 11561066. 10: Rademacher DJ, Anders KA, Riley MG, Nesbitt JT, Steinpreis RE. Determination of the place conditioning and locomotor effects of amperozide in rats: a comparison with cocaine. Exp Clin Psychopharmacol. 2000 Aug;8(3):434-43. PubMed PMID: 10975635. 11: Ichikawa J, Meltzer HY. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain Res. 2000 Mar 10;858(2):252-63. PubMed PMID: 10708676. 12: Carboni E, Rolando MT, Silvagni A, Di Chiara G. Increase of dialysate dopamine in the bed nucleus of stria terminalis by clozapine and related neuroleptics. Neuropsychopharmacology. 2000 Feb;22(2):140-7. PubMed PMID: 10649827. 13: Rådberg K, Botermans J, Weström BR, Pierzynowski SG. Depressive effects of anesthesia or sedation on exocrine pancreatic function in pigs. Lab Anim Sci. 1999 Dec;49(6):662-4. PubMed PMID: 10638505. 14: Arolfo MP, McMillen BA. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec 1-15;68(1-2):93-8. PubMed PMID: 10627067. 15: Rademacher DJ, Kuppinger HE, Thompson KJ, Harrington A, Kaczmarek HJ, Kopish AJ, Steinpreis RE. The effects of amperozide on cocaine-induced social withdrawal in rats. Behav Brain Res. 1999 Feb 15;99(1):75-80. PubMed PMID: 10512574. 16: Wettstein JG, Host M, Hitchcock JM. Selectivity of action of typical and atypical anti-psychotic drugs as antagonists of the behavioral effects of 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI). Prog Neuropsychopharmacol Biol Psychiatry. 1999 Apr;23(3):533-44. PubMed PMID: 10378235. 17: Jones EA, McMillen BA. The cardiovascular effects of amperozide: interactions with cocaine. Pharmacol Toxicol. 1999 Feb;84(2):53-8. PubMed PMID: 10068147. 18: Kuroki T, Meltzer HY, Ichikawa J. Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens. J Pharmacol Exp Ther. 1999 Feb;288(2):774-81. PubMed PMID: 9918588. 19: Steinpreis RE, Moser L, Parret F, Rutell E, Panos J. The effects of the atypical antipsychotic amperozide on vacuous jaw movements in rats: a novel dose response profile. Psychopharmacology (Berl). 1998 Jul;138(2):107-13. PubMed PMID: 9718279. 20: Ichikawa J, Kuroki T, Dai J, Meltzer HY. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. Eur J Pharmacol. 1998 Jun 19;351(2):163-71. PubMed PMID: 9686999.