Synonym
Amphethinile; Amphetinile;
IUPAC/Chemical Name
2-amino-5-(phenylthio)-1H-indole-3-carbonitrile
InChi Key
LHNIUFUSFGYJEO-UHFFFAOYSA-N
InChi Code
1S/C15H11N3S/c16-9-13-12-8-11(6-7-14(12)18-15(13)17)19-10-4-2-1-3-5-10/h1-8,18H,17H2
SMILES Code
NC1=C(C#N)C2=C(N1)C=CC(SC3=CC=CC=C3)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
265.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: McGown AT, Ewen C, Smith DB, Fox BW. Pre-clinical studies of a novel anti- mitotic agent, amphethinile. Br J Cancer. 1988 Feb;57(2):157-9. doi: 10.1038/bjc.1988.32. PMID: 3358906; PMCID: PMC2246435.
2: Smith DB, Ewen C, Mackintosh J, Fox BW, Thatcher N, Scarffe JH, Vezin R, Crowther D. A phase I and pharmacokinetic study of amphethinile. Br J Cancer. 1988 Jun;57(6):623-7. doi: 10.1038/bjc.1988.142. PMID: 3408647; PMCID: PMC2246468.
3: Graham MA, Workman P. The impact of pharmacokinetically guided dose escalation strategies in phase I clinical trials: critical evaluation and recommendations for future studies. Ann Oncol. 1992 May;3(5):339-47. doi: 10.1093/oxfordjournals.annonc.a058203. PMID: 1616887.
4: McGown AT, Fox BW. Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile. Anticancer Drug Des. 1989 Mar;3(4):249-54. PMID: 2930627.
5: McGown AT, Fox BW. Interaction of the novel agent amphethinile with tubulin. Br J Cancer. 1989 Jun;59(6):865-8. doi: 10.1038/bjc.1989.183. PMID: 2736224; PMCID: PMC2246728.
6: Acheson A, de Wit H. Bupropion improves attention but does not affect impulsive behavior in healthy young adults. Exp Clin Psychopharmacol. 2008 Apr;16(2):113-23. doi: 10.1037/1064-1297.16.2.113. PMID: 18489015; PMCID: PMC4270475.
7: Zwartsen A, de Korte T, Nacken P, de Lange DW, Westerink RHS, Hondebrink L. Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. J Mol Cell Cardiol. 2019 Nov;136:102-112. doi: 10.1016/j.yjmcc.2019.09.007. Epub 2019 Sep 14. PMID: 31526813.
8: Nishiguchi M, Kinoshita H, Higasa K, Taniguchi T, Ouchi H, Minami T, Marukawa S, Yoshinaga K, Yamauchi J, Aoki S, Hishida S. [The false positive reaction of the Triage panel drug-of-abuse by herbal drugs ma-huang (Ephedra sinica (Ephedraceae))]. Nihon Hoigaku Zasshi. 2001 Nov;55(3):331-8. Japanese. PMID: 11905042.
