HBX19818 | CAS#1426944-49-1 | USP7 inhibitor

MedKoo Cat#: 562449 | Name: HBX19818

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HBX19818 is a selective inhibitor of USP7.

Chemical Structure

HBX19818

CAS#1426944-49-1

Theoretical Analysis

MedKoo Cat#: 562449

Name: HBX19818

CAS#: 1426944-49-1

Chemical Formula: C25H28ClN3O

Exact Mass: 421.1921

Molecular Weight: 421.97

Elemental Analysis: C, 71.16; H, 6.69; Cl, 8.40; N, 9.96; O, 3.79

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,850.00	2 Weeks
1g	USD 3,850.00	2 Weeks
2g	USD 6,450.00	2 Weeks

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Related CAS #

No Data

Synonym

HBX19818; HBX-19818; HBX 19818; HBX 19,818; HBX19,818; HBX-19,818

IUPAC/Chemical Name

9-Chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-2-acridinecarboxamide

InChi Key

ZCALMLVWZSQGGR-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H28ClN3O/c1-29(17-18-8-3-2-4-9-18)15-7-14-27-25(30)19-12-13-23-21(16-19)24(26)20-10-5-6-11-22(20)28-23/h2-4,8-9,12-13,16H,5-7,10-11,14-15,17H2,1H3,(H,27,30)

SMILES Code

O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	12.5	29.62
	Ethanol	5.0	0.47
	Water	5.0	0.47

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Cremer A, Stegmaier K. Targeting DUBs to degrade oncogenic proteins. Br J Cancer. 2020 Apr;122(8):1121-1123. doi: 10.1038/s41416-020-0728-7. Epub 2020 Feb 4. PMID: 32015509; PMCID: PMC7156467. 2: Gao Y, Wang Y, Zhou C, Kong S, Lu J, Wang H, Yang J. Ubiquitin-specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice. Dev Growth Differ. 2019 Feb;61(2):176-185. doi: 10.1111/dgd.12594. Epub 2019 Jan 9. PMID: 30628051.