Pyrazolam | CAS#39243-02-2 | benzodiazepine

MedKoo Cat#: 145983 | Name: Pyrazolam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyrazolam is a benzodiazepine derivative that is primarily used for its anxiolytic (anti-anxiety) effects. It works by binding to the GABA-A receptors in the brain, enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), which has inhibitory effects on neural activity, leading to a calming and sedative effect. Pyrazolam is commonly used to treat anxiety, stress, and panic disorders, as it helps to reduce symptoms like agitation, restlessness, and nervousness. Its mechanism involves the modulation of GABAergic activity, which plays a critical role in regulating mood and reducing anxiety.

Chemical Structure

Pyrazolam

CAS#39243-02-2

Theoretical Analysis

MedKoo Cat#: 145983

Name: Pyrazolam

CAS#: 39243-02-2

Chemical Formula: C17H19ClN4O2

Exact Mass: 346.1200

Molecular Weight: 346.82

Elemental Analysis: C, 58.87; H, 5.52; Cl, 10.22; N, 16.16; O, 9.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pyrazolam; Pirazolam;

IUPAC/Chemical Name

8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

InChi Key

BGRWSFIQQPVEML-UHFFFAOYSA-N

InChi Code

1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3

SMILES Code

CC1=NN=C2CN=C(C3=CC=CC=N3)C4=CC(Br)=CC=C4N12

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lehmann S, Sczyslo A, Froch-Cortis J, Rothschild MA, Thevis M, Andresen- Streichert H, Mercer-Chalmers-Bender K. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic Sci Int. 2019 Oct;303:109959. doi: 10.1016/j.forsciint.2019.109959. Epub 2019 Sep 12. PMID: 31546164. 2: Mullin A, Scott M, Vaccaro G, Floresta G, Arillotta D, Catalani V, Corkery JM, Stair JL, Schifano F, Guirguis A. Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques. Pharmacy (Basel). 2024 Jan 12;12(1):13. doi: 10.3390/pharmacy12010013. PMID: 38251407; PMCID: PMC10801481. 3: Wu D, Fu L. Recent findings and advancements in the detection of designer benzodiazepines: a brief review. Arh Hig Rada Toksikol. 2023 Dec 29;74(4):224-231. doi: 10.2478/aiht-2023-74-3771. PMID: 38146763; PMCID: PMC10750316. 4: O'Connor LC, Torrance HJ, McKeown DA. ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis® Benzodiazepine Kit. J Anal Toxicol. 2016 Mar;40(2):159-61. doi: 10.1093/jat/bkv122. Epub 2015 Oct 29. PMID: 26518230. 5: Abouchedid R, Gilks T, Dargan PI, Archer JRH, Wood DM. Assessment of the Availability, Cost, and Motivations for Use over Time of the New Psychoactive Substances-Benzodiazepines Diclazepam, Flubromazepam, and Pyrazolam-in the UK. J Med Toxicol. 2018 Jun;14(2):134-143. doi: 10.1007/s13181-018-0659-3. Epub 2018 Apr 18. PMID: 29671244; PMCID: PMC5962469. 6: Manchester KR, Waters L, Haider S, Maskell PD. The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. Forensic Toxicol. 2022 Jul;40(2):349-356. doi: 10.1007/s11419-022-00616-y. Epub 2022 Mar 16. PMID: 36454409; PMCID: PMC9715504. 7: Pettersson Bergstrand M, Meyer MR, Beck O, Helander A. Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry. Drug Test Anal. 2018 Mar;10(3):496-506. doi: 10.1002/dta.2243. Epub 2017 Aug 29. PMID: 28677876. 8: Łukasik-Głębocka M, Sommerfeld K, Teżyk A, Zielińska-Psuja B, Panieński P, Żaba C. Flubromazolam--A new life-threatening designer benzodiazepine. Clin Toxicol (Phila). 2016;54(1):66-8. doi: 10.3109/15563650.2015.1112907. Epub 2015 Nov 20. PMID: 26585557. 9: El Balkhi S, Monchaud C, Herault F, Géniaux H, Saint-Marcoux F. Designer benzodiazepines' pharmacological effects and potencies: How to find the information. J Psychopharmacol. 2020 Sep;34(9):1021-1029. doi: 10.1177/0269881119901096. Epub 2020 Jan 23. PMID: 31971477. 10: Høiseth G, Tuv SS, Karinen R. Blood concentrations of new designer benzodiazepines in forensic cases. Forensic Sci Int. 2016 Nov;268:35-38. doi: 10.1016/j.forsciint.2016.09.006. Epub 2016 Sep 16. PMID: 27685473. 11: Brunetti P, Giorgetti R, Tagliabracci A, Huestis MA, Busardò FP. Designer Benzodiazepines: A Review of Toxicology and Public Health Risks. Pharmaceuticals (Basel). 2021 Jun 11;14(6):560. doi: 10.3390/ph14060560. PMID: 34208284; PMCID: PMC8230725. 12: Pettersson Bergstrand M, Richter LHJ, Maurer HH, Wagmann L, Meyer MR. In vitro glucuronidation of designer benzodiazepines by human UDP- glucuronyltransferases. Drug Test Anal. 2019 Jan;11(1):45-50. doi: 10.1002/dta.2463. Epub 2018 Aug 9. PMID: 29996009. 13: DeFreitas L, Fonseca Pego AM, Kronstrand R, Lendoiro E, de Castro-Ríos A, Concheiro M. Fast and Sensitive Method for the Determination of 17 Designer Benzodiazepines in Hair by Liquid Chromatography-Tandem Mass Spectrometry. J Anal Toxicol. 2022 Oct 14;46(8):852-859. doi: 10.1093/jat/bkac044. PMID: 35748814. 14: Carpenter JE, Murray BP, Dunkley C, Kazzi ZN, Gittinger MH. Designer benzodiazepines: a report of exposures recorded in the National Poison Data System, 2014-2017. Clin Toxicol (Phila). 2019 Apr;57(4):282-286. doi: 10.1080/15563650.2018.1510502. Epub 2018 Nov 15. PMID: 30430874. 15: Moosmann B, Huppertz LM, Hutter M, Buchwald A, Ferlaino S, Auwärter V. Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics. J Mass Spectrom. 2013 Nov;48(11):1150-9. doi: 10.1002/jms.3279. PMID: 24259203. 16: Puzyrenko A, Wang D, Schneider R, Wallace G, Schreiber S, Brandt K, Gunsolus IL. Urine Drug Screening in the Era of Designer Benzodiazepines: Comparison of Three Immunoassay Platforms, LC-QTOF-MS and LC-MS-MS. J Anal Toxicol. 2022 Aug 13;46(7):712-718. doi: 10.1093/jat/bkab108. PMID: 34557900. 17: Pettersson Bergstrand M, Helander A, Hansson T, Beck O. Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays. Drug Test Anal. 2017 Apr;9(4):640-645. doi: 10.1002/dta.2003. Epub 2016 Jul 1. PMID: 27366870. 18: Mei V, Concheiro M, Pardi J, Cooper G. Validation of an LC-MS/MS Method for the Quantification of 13 Designer Benzodiazepines in Blood. J Anal Toxicol. 2019 Oct 17;43(9):688-695. doi: 10.1093/jat/bkz063. PMID: 31436813. 19: Bade R, Ghetia M, White JM, Gerber C. Determination of prescribed and designer benzodiazepines and metabolites in influent wastewater. Anal Methods. 2020 Jul 28;12(28):3637-3644. doi: 10.1039/d0ay00560f. Epub 2020 Jul 6. PMID: 32701083. 20: Griffeuille P, El Balkhi S, Dulaurent S, Saint-Marcoux F. Probe Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantification of Benzodiazepines. Ther Drug Monit. 2024 Aug 1;46(4):522-529. doi: 10.1097/FTD.0000000000001189. Epub 2024 Mar 18. PMID: 38498915.