Synonym
Alnustone; CHEMBL461082;
IUPAC/Chemical Name
(4E,6E)-1,7-diphenylhepta-4,6-dien-3-one
InChi Key
OWMJDOUOHDOUFG-FNCQTZNRSA-N
InChi Code
InChI=1S/C19H18O/c20-19(16-15-18-11-5-2-6-12-18)14-8-7-13-17-9-3-1-4-10-17/h1-14H,15-16H2/b13-7+,14-8+
SMILES Code
O=C(/C=C/C=C/C1=CC=CC=C1)CCC2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
262.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang L, Cheng L, Ma L, Ahmad Farooqi A, Qiao G, Zhang Y, Ye H, Liu M, Huang
J, Yang X, Lin X, Cao S. Alnustone inhibits the growth of hepatocellular
carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis. Phytother Res. 2022
Jan;36(1):525-542. doi: 10.1002/ptr.7337. Epub 2021 Nov 30. PMID: 34847624.
2: Zhang C, Deng Y, Wang X, Shi L, Zhan B, Hou N, Liu S, Bao M, Chi G, Fang T.
Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin
and sortase A. Fitoterapia. 2022 Oct;162:105261. doi:
10.1016/j.fitote.2022.105261. Epub 2022 Aug 6. PMID: 35944753.
3: Song Y, Zhou Y, Yan XT, Bi JB, Qiu X, Bian Y, Wang KF, Zhang Y, Feng XS.
Pharmacokinetics and Tissue Distribution of Alnustone in Rats after Intravenous
Administration by Liquid Chromatography-Mass Spectrometry. Molecules. 2019 Sep
2;24(17):3183. doi: 10.3390/molecules24173183. PMID: 31480657; PMCID:
PMC6749364.
4: Li Z. Comment on: Alnustone inhibits the growth of hepatocellular carcinoma
via reactive oxygen species-mediated PI3K/Akt/mTOR/p70S6K axis. Phytother Res.
2023 Jun;37(6):2215-2216. doi: 10.1002/ptr.7708. Epub 2022 Dec 22. PMID:
36560899.
