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MedKoo Cat#: 562429 | Name: SPP-86
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPP-86 is a potent RET inhibitor.

Chemical Structure

SPP-86
SPP-86
CAS#1357349-91-7

Theoretical Analysis

MedKoo Cat#: 562429

Name: SPP-86

CAS#: 1357349-91-7

Chemical Formula: C16H15N5

Exact Mass: 277.1327

Molecular Weight: 277.33

Elemental Analysis: C, 69.29; H, 5.45; N, 25.25

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 weeks
25mg USD 850.00 2 weeks
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Related CAS #
No Data
Synonym
SPP-86; SPP 86; SPP86;
IUPAC/Chemical Name
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChi Key
JQOIRTDBHMDWMT-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
SMILES Code
NC1=C2C(N(C(C)C)N=C2C#CC3=CC=CC=C3)=NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and ethanol
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SPP-86 is a potent RET inhibitor (IC50 = 8 nM).
In vitro activity:
To be determined
In vivo activity:
To be determined
Solvent mg/mL mM comments
Solubility
DMSO 27.7 100.00
Ethanol 5.6 20.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 277.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Alao JP, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853. doi: 10.1186/1471-2407-14-853. PubMed PMID: 25409876; PubMed Central PMCID: PMC4252022.