Sedanolide | CAS#6415-59-4 | natural phthalide

MedKoo Cat#: 461969 | Name: Sedanolide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice.

Chemical Structure

Sedanolide

CAS#6415-59-4

Theoretical Analysis

MedKoo Cat#: 461969

Name: Sedanolide

CAS#: 6415-59-4

Chemical Formula: C12H18O2

Exact Mass: 194.1307

Molecular Weight: 194.27

Elemental Analysis: C, 74.19; H, 9.34; O, 16.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sedanolide; Neocnidilide

IUPAC/Chemical Name

1(3H)-Isobenzofuranone, 3-butyl-3a,4,5,6-tetrahydro-

InChi Key

UPJFTVFLSIQQAV-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H18O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h7,9,11H,2-6,8H2,1H3

SMILES Code

O=C1OC(CCCC)C2CCCC=C21

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 194.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hsieh SL, Chen CT, Wang JJ, Kuo YH, Li CC, Hsieh LC, Wu CC. Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. Int J Oncol. 2015 Dec;47(6):2240-6. doi: 10.3892/ijo.2015.3206. Epub 2015 Oct 15. PubMed PMID: 26500073. 2: Woods JA, Jewell C, O'Brien NM. Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines. In Vitr Mol Toxicol. 2001 Fall;14(3):233-40. PubMed PMID: 11846995. 3: Sowbhagya HB. Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Crit Rev Food Sci Nutr. 2014;54(3):389-98. doi: 10.1080/10408398.2011.586740. Review. PubMed PMID: 24188309.