Synonym
Spr 210; SG 210; Spr210; SG210; Spr-210; SG-210
IUPAC/Chemical Name
2H-1,4-Benzothiazine-2-aceticacid, 3,4-dihydro-3-oxo-4-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
InChi Key
BUYWFAJWTSIACV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H11F3N2O3S2/c19-8-5-9(20)17-16(15(8)21)22-13(28-17)7-23-10-3-1-2-4-11(10)27-12(18(23)26)6-14(24)25/h1-5,12H,6-7H2,(H,24,25)
SMILES Code
O=C(O)CC1SC2=CC=CC=C2N(CC3=NC4=C(F)C(F)=CC(F)=C4S3)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
424.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Matsui T, Nakamura Y, Ishikawa H, Matsuura A, Kobayashi F. Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol. 1994 Feb;64(2):115-24. PubMed PMID: 8028228.
2: Aotsuka T, Hosono H, Kurihara T, Nakamura Y, Matsui T, Kobayashi F. Novel and potent aldose reductase inhibitors: 4-benzyl- and 4-(benzothiazol-2-ylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-ac etic acid derivatives. Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1264-71. PubMed PMID: 8069975.
3: Akira T, Naka H. [SG-210]. Nihon Rinsho. 1997 Nov;55 Suppl:216-20. Review. Japanese. PubMed PMID: 9434470.
4: Horie S, Nagai H, Yuuki T, Narita Y, Tsuda Y, Nakajima T, Nakamura N. Effect of SG-210, a novel aldose reductase inhibitor, on impaired polyol pathway in rats received diabetic manipulations. J Diabetes Complications. 1998 May-Jun;12(3):163-9. PubMed PMID: 9618072.
5: Weikert LF, Lopez JP, Abdolrasulnia R, Chroneos ZC, Shepherd VL. Surfactant protein A enhances mycobacterial killing by rat macrophages through a nitric oxide-dependent pathway. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L216-23. PubMed PMID: 10926544.
6: Ino-Ue M, Zhang L, Naka H, Kuriyama H, Yamamoto M. Polyol metabolism of retrograde axonal transport in diabetic rat large optic nerve fiber. Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4055-8. PubMed PMID: 11095594.
7: Azuma M, Inoue E, Oka T, Shearer TR. Proteolysis by calpain is an underlying mechanism for formation of sugar cataract in rat lens. Curr Eye Res. 1995 Jan;14(1):27-34. PubMed PMID: 7720403.
