Rauhimbine | CAS#66634-44-4

MedKoo Cat#: 341234 | Name: Rauhimbine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rauhimbine is a biochemical.

Chemical Structure

Rauhimbine

CAS#66634-44-4

Theoretical Analysis

MedKoo Cat#: 341234

Name: Rauhimbine

CAS#: 66634-44-4

Chemical Formula: C21H27ClN2O3

Exact Mass: 390.1710

Molecular Weight: 390.91

Elemental Analysis: C, 64.52; H, 6.96; Cl, 9.07; N, 7.17; O, 12.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Rauhimbine; Corynanthine Hydrochloride

IUPAC/Chemical Name

methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride

InChi Key

PIPZGJSEDRMUAW-VYDVLXQVSA-N

InChi Code

InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19-;/m0./s1

SMILES Code

COC([C@@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@H]3C4=C(C5=CC=CC=C5N4)CCN3C2)=O.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 390.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stipica Safic I, Pecotic R, Pavlinac Dodig I, Dogas Z, Valic Z, Valic M. Phrenic long term depression evoked by intermittent hypercapnia is modulated by serotonergic and adrenergic receptors in raphe nuclei. J Neurophysiol. 2018 Apr 4. doi: 10.1152/jn.00776.2017. [Epub ahead of print] PubMed PMID: 29617215. 2: Williamson RH, Muller LL, Blair C. THE USE OF KETAMINE-XYLAZINE OR BUTORPHANOL-AZAPERONE-MEDETOMIDINE TO IMMOBILIZE AMERICAN BLACK BEARS ( URSUS AMERICANUS). J Wildl Dis. 2018 Apr 4. doi: 10.7589/2017-10-255. [Epub ahead of print] PubMed PMID: 29616881. 3: Franco-Belussi L, De Oliveira C, Sköld HN. Regulation of eye and jaw colouration in three-spined stickleback Gasterosteus aculeatus. J Fish Biol. 2018 Mar 25. doi: 10.1111/jfb.13620. [Epub ahead of print] PubMed PMID: 29577284. 4: Cippitelli A, Brunori G, Schoch J, Armishaw CJ, Wu J, Zaveri NT, Giulianotti MA, Welmaker GS, Toll L. Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs. Psychopharmacology (Berl). 2018 Mar 23. doi: 10.1007/s00213-018-4883-y. [Epub ahead of print] PubMed PMID: 29572652. 5: Kotagale NR, Ali MT, Chopde CT, Umekar MJ, Taksande BG. Agmatine inhibits nicotine withdrawal induced cognitive deficits in inhibitory avoidance task in rats: Contribution of α(2)-adrenoceptors. Pharmacol Biochem Behav. 2018 Apr;167:42-49. doi: 10.1016/j.pbb.2018.03.002. Epub 2018 Mar 10. PubMed PMID: 29530492. 6: Samur DN, Arslan R, Aydın S, Bektas N. Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms. Eur J Pharmacol. 2018 May 15;827:208-214. doi: 10.1016/j.ejphar.2018.03.006. Epub 2018 Mar 6. PubMed PMID: 29522726. 7: Chen H, Sun X, Yang X, Hou Y, Yu X, Wang Y, Wu J, Liu D, Wang H, Yu J, Yi W. Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway. Bosn J Basic Med Sci. 2018 Feb 20. doi: 10.17305/bjbms.2018.2400. [Epub ahead of print] PubMed PMID: 29510084. 8: Uchida M, Kobayashi O. Novel effect of α-lactalbumin on the yohimbine-induced hot flush increase of the tail skin temperature in ovariectomized rats. Biosci Biotechnol Biochem. 2018 Mar 5:1-7. doi: 10.1080/09168451.2018.1444976. [Epub ahead of print] PubMed PMID: 29504865. 9: Rtibi K, Selmi S, Grami D, Amri M, Sebai H, Marzouki L. Opposite Effect of Opuntia ficus-indica L. Juice Depending on Fruit Maturity Stage on Gastrointestinal Physiological Parameters in Rat. J Med Food. 2018 Feb 28. doi: 10.1089/jmf.2017.0121. [Epub ahead of print] PubMed PMID: 29489444. 10: Momohara Y, Aonuma H, Nagayama T. Tyraminergic modulation of agonistic outcomes in crayfish. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Feb 27. doi: 10.1007/s00359-018-1255-3. [Epub ahead of print] PubMed PMID: 29488014. 11: El Moussawi L, Chakkour M, Kreydiyyeh SI. Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2. PLoS One. 2018 Feb 21;13(2):e0193139. doi: 10.1371/journal.pone.0193139. eCollection 2018. PubMed PMID: 29466417; PubMed Central PMCID: PMC5821373. 12: Gálosi R, Petykó Z, Kállai V, Tóth A, Ollmann T, Péczely L, Kovács A, Berta B, Lénárd L. Destruction of noradrenergic terminals increases dopamine concentration and reduces dopamine metabolism in the medial prefrontal cortex. Behav Brain Res. 2018 May 15;344:57-64. doi: 10.1016/j.bbr.2018.02.016. Epub 2018 Feb 14. PubMed PMID: 29454007. 13: Tuerk PW, Wangelin BC, Powers MB, Smits JAJ, Acierno R, Myers US, Orr SP, Foa EB, Hamner MB. Augmenting treatment efficiency in exposure therapy for PTSD: a randomized double-blind placebo-controlled trial of yohimbine HCl. Cogn Behav Ther. 2018 Feb 15:1-21. doi: 10.1080/16506073.2018.1432679. [Epub ahead of print] PubMed PMID: 29448886. 14: Ramamoorthy MD, Kumar A, Ayyau M, Dhiraviam KN. Reserpine induces apoptosis and cell cycle arrest in hormone independent prostate cancer cells through mitochondrial membrane potential failure. Anticancer Agents Med Chem. 2018 Feb 9. doi: 10.2174/1871520618666180209152215. [Epub ahead of print] PubMed PMID: 29424320. 15: Zhou Y, Zhou X, Zhou W, Pang Q, Wang Z. The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury. Acta Cir Bras. 2018 Jan;33(1):1-13. doi: 10.1590/s0102-865020180010000001. PubMed PMID: 29412228. 16: Araújo JRC, Júnior JMAM, Damasceno MBMV, Santos SAAR, Vieira-Neto AE, Lobo MDP, Campos AR, Moreira RA, Monteiro-Moreira ACO. Neuropharmacological characterization of frutalin in mice: Evidence of an antidepressant-like effect mediated by the NMDA receptor/NO/cGMP pathway. Int J Biol Macromol. 2018 Jun;112:548-554. doi: 10.1016/j.ijbiomac.2018.01.180. Epub 2018 Jan 31. PubMed PMID: 29408007. 17: Margittai Z, van Wingerden M, Schnitzler A, Joëls M, Kalenscher T. Dissociable roles of glucocorticoid and noradrenergic activation on social discounting. Psychoneuroendocrinology. 2018 Apr;90:22-28. doi: 10.1016/j.psyneuen.2018.01.015. Epub 2018 Jan 31. PubMed PMID: 29407513. 18: Lueckel M, Panitz C, Nater UM, Mueller EM. Reliability and robustness of feedback-evoked brain-heart coupling after placebo, dopamine, and noradrenaline challenge. Int J Psychophysiol. 2018 Jan 31. pii: S0167-8760(17)30366-5. doi: 10.1016/j.ijpsycho.2018.01.010. [Epub ahead of print] PubMed PMID: 29382555. 19: Barlow RL, Dalley JW, Pekcec A. Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task. Psychopharmacology (Berl). 2018 Apr;235(4):1199-1209. doi: 10.1007/s00213-018-4836-5. Epub 2018 Jan 26. PubMed PMID: 29374304; PubMed Central PMCID: PMC5869891. 20: Park SH, Lee JR, Jang SP, Park SH, Lee HJ, Hong JW, Suh HW. Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. Neuropeptides. 2018 Apr;68:7-14. doi: 10.1016/j.npep.2018.01.002. Epub 2018 Feb 1. PubMed PMID: 29366515.