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MedKoo Cat#: 341199 | Name: Pit-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PIT-1 represents a new class of molecules referred to as PITenins. In vivo, a PIT-1 analog displays significant inhibition on tumor angiogenesis and metastasis.

Chemical Structure

Pit-1
Pit-1
CAS#53501-41-0

Theoretical Analysis

MedKoo Cat#: 341199

Name: Pit-1

CAS#: 53501-41-0

Chemical Formula: C14H10ClN3O4S

Exact Mass: 351.0081

Molecular Weight: 351.76

Elemental Analysis: C, 47.80; H, 2.87; Cl, 10.08; N, 11.95; O, 18.19; S, 9.11

Price and Availability

Size Price Availability Quantity
5mg USD 450.00
25mg USD 715.00
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Related CAS #
No Data
Synonym
Pit-1; Pit 1; Pit1.
IUPAC/Chemical Name
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide
InChi Key
RIGXBXPAOGDDIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10ClN3O4S/c15-10-6-9(18(21)22)7-11(12(10)19)16-14(23)17-13(20)8-4-2-1-3-5-8/h1-7,19H,(H2,16,17,20,23)
SMILES Code
O=C(NC(NC1=CC([N+]([O-])=O)=CC(Cl)=C1O)=S)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Z, Wu Y, Sun J, Wang R, Bao X. Characteristics and treatment of a silent somatotroph tumor that had transformed to a functional type: a case report and literature review. Gland Surg. 2024 Jul 30;13(7):1322-1330. doi: 10.21037/gs-24-79. Epub 2024 Jul 24. PMID: 39175709; PMCID: PMC11336798. 2: Buffin-Meyer B, Richard J, Guigonis V, Weber S, König J, Heidet L, Moussaoui N, Vu JP, Faguer S, Casemayou A, Prakash R, Baudouin V, Hogan J, Alexandrou D, Bockenhauer D, Bacchetta J, Ranchin B, Pruhova S, Zieg J, Lahoche A, Okorn C, Antal-Kónya V, Morin D, Becherucci F, Habbig S, Liebau MC, Mauras M, Nijenhuis T, Llanas B, Mekahli D, Thumfart J, Tönshoff B, Massella L, Eckart P, Cloarec S, Cruz A, Patzer L, Roussey G, Vrillon I, Dunand O, Bessenay L, Taroni F, Zaniew M, Louillet F, Bergmann C, Schaefer F, van Eerde AM, Schanstra JP, Decramer S; HNF1B variant study group. Renal and Extrarenal Phenotypes in Patients With HNF1B Variants and Chromosome 17q12 Microdeletions. Kidney Int Rep. 2024 May 16;9(8):2514-2526. doi: 10.1016/j.ekir.2024.05.007. PMID: 39156164; PMCID: PMC11328578. 3: Han J, Lv X, He L, Liu M, Qu H, Xi L, Zhang L, Ma B, Shi C, Yang G, Wang Z. MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D3. Poult Sci. 2024 Jul 2;103(10):104052. doi: 10.1016/j.psj.2024.104052. Epub ahead of print. PMID: 39067128; PMCID: PMC11338088. 4: Deng C, Gu L, Sun J, Feng M, Bao X. Intracranial seeding of pituitary neuroendocrine tumor: a case report. Gland Surg. 2024 Jun 30;13(6):1108-1115. doi: 10.21037/gs-24-36. Epub 2024 Jun 19. PMID: 39015715; PMCID: PMC11247583. 5: Urban-Sosa VA, Ávila-Mendoza J, Carranza M, Martínez-Moreno CG, Luna M, Arámburo C. Differential peptide-dependent regulation of growth hormone (GH): A comparative analysis in pituitary cultures of reptiles, birds, and mammals. Heliyon. 2024 Jun 14;10(12):e33060. doi: 10.1016/j.heliyon.2024.e33060. PMID: 38994081; PMCID: PMC11238054. 6: Kwon JH, Kim DK, Cho YE, Kwun IS. Zinc Action in Vascular Calcification. Prev Nutr Food Sci. 2024 Jun 30;29(2):118-124. doi: 10.3746/pnf.2024.29.2.118. PMID: 38974586; PMCID: PMC11223917. 7: Chen W, Bedar M, Zhou Q, Ren X, Kang Y, Huang KX, Rubino G, Kolliopoulos V, Moghadam S, Cascavita CT, Taylor JM, Chevalier JM, Harley BAC, Lee JC. Correlating Material Properties to Osteoprotegerin Expression on Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffolds. Adv Healthc Mater. 2024 Jun 17:e2401037. doi: 10.1002/adhm.202401037. Epub ahead of print. PMID: 38885525. 8: Woo CS, Ho RS, Ho G, Lau HT, Fong CH, Chang JY, Leung EK, Tang LC, Ma IK, Lee AC, Lui DT, Woo YC, Chow WS, Leung GK, Tan KC, Lam KS, Lee CH. A clinicopathological study of non-functioning pituitary neuroendocrine tumours using the World Health Organization 2022 classification. Front Endocrinol (Lausanne). 2024 May 2;15:1368944. doi: 10.3389/fendo.2024.1368944. PMID: 38756997; PMCID: PMC11096571. 9: Liu F, Zang Y, Feng L, Shi X, Wu W, Liu X, Song Y, Xu J, Gui S, Chen X. Concomitant Prediction of the Ki67 and PIT-1 Expression in Pituitary Adenoma Using Different Radiomics Models. J Imaging Inform Med. 2024 May 15. doi: 10.1007/s10278-024-01121-x. Epub ahead of print. PMID: 38750186. 10: Xu L, Jin T, Lou A, Guan J, Zhang X, Wang H, Guan L. The effect of miR-23b-3p on regulating GH by targeting POU1F1 in Yanbian yellow cattle. Anim Biotechnol. 2024 Nov;35(1):2346808. doi: 10.1080/10495398.2024.2346808. Epub 2024 May 13. PMID: 38739483. 11: Stadler KA, Ortiz-Joya LJ, Singh Sahrawat A, Buhlheller C, Gruber K, Pavkov- Keller T, O'Hagan TB, Guarné A, Pulido S, Marín-Villa M, Zangger K, Gubensäk N. Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease. Sci Rep. 2024 May 2;14(1):10039. doi: 10.1038/s41598-024-59654-8. PMID: 38693166; PMCID: PMC11063076. 12: Urai S, Tomofuji S, Bando H, Kanzawa M, Yamamoto M, Fukuoka H, Tsuda M, Iguchi G, Ogawa W. The early-stage clinical course of anti-pituitary-specific transcription factor-1 hypophysitis diagnosed post-immune checkpoint inhibitor treatment: A case with review of literature. J Neuroendocrinol. 2024 Jun;36(6):e13395. doi: 10.1111/jne.13395. Epub 2024 Apr 17. PMID: 38631695. 13: Guaraldi F, Ambrosi F, Ricci C, Di Sciascio L, Asioli S. Histopathology of growth hormone-secreting pituitary tumors: State of the art and new perspectives. Best Pract Res Clin Endocrinol Metab. 2024 May;38(3):101894. doi: 10.1016/j.beem.2024.101894. Epub 2024 Apr 2. PMID: 38614953. 14: Shen AL, Moran SM, Glover EN, Lin BC, Carney PR, Bradfield CA. Familial isolated pituitary adenoma is independent of Ahr genotype in a novel mouse model of disease. Heliyon. 2024 Mar 26;10(7):e28231. doi: 10.1016/j.heliyon.2024.e28231. PMID: 38590848; PMCID: PMC10999881. 15: Guo C, Quan Z, Ke J, Zang H, Teng Q, Li X, Peng D, Wang P. Hypoxia-Inducible Factor-1α Regulates High Phosphate-Induced Vascular Calcification via Type III Sodium-Dependent Phosphate Cotransporter 1. Cardiol Res Pract. 2024 Mar 26;2024:6346115. doi: 10.1155/2024/6346115. PMID: 38566807; PMCID: PMC10987242. 16: Wu Z, Ma L, Su D, Xiagedeer B. The disrupting effect of chlormequat chloride on growth hormone is associated with pregnancy. Toxicol Lett. 2024 May 1;395:17-25. doi: 10.1016/j.toxlet.2024.03.004. Epub 2024 Mar 27. PMID: 38552810. 17: Navin AK, Aruldhas MM, Mani KK, Navaneethabalakrishnan S, Venkatachalam S, Banu SK. Unraveling Hypothalamus-Pituitary dysregulation: Hypergonadotropism in F1 progeny due to prenatal exposure to hexavalent chromium. J Biochem Mol Toxicol. 2024 Apr;38(4):e23699. doi: 10.1002/jbt.23699. PMID: 38532648. 18: Lenders NF, Thompson TJ, Chui J, Low J, Inder WJ, Earls PE, McCormack AI. Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2. Pituitary. 2024 Jun;27(3):248-258. doi: 10.1007/s11102-024-01385-0. Epub 2024 Mar 14. PMID: 38483762; PMCID: PMC11150322. 19: Paramita P, Shilpa R, Nandeesh BN, Yasha TC, Vani S. Delineating the Spectrum of Pituitary Adenoma Based on the WHO 2017 Classification. Neurol India. 2024 Jan 1;72(1):96-101. doi: 10.4103/neuroindia.NI_913_20. Epub 2024 Feb 29. PMID: 38443009. Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A. Inhibition of cell migration by PITENINs: the role of ARF6. Oncogene. 2012 Sep 27;31(39):4317-32. doi: 10.1038/onc.2011.593. Epub 2011 Dec 19. PMID: 22179837; PMCID: PMC3310973.