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MedKoo Cat#: 562106 | Name: AKCI

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AKCI is a PPI inhibitor. It acts by targeting the AURKC-IκBα interaction.

Chemical Structure

AKCI
AKCI
CAS#669750-88-3

Theoretical Analysis

MedKoo Cat#: 562106

Name: AKCI

CAS#: 669750-88-3

Chemical Formula: C19H27N7O

Exact Mass: 369.2277

Molecular Weight: 369.47

Elemental Analysis: C, 61.77; H, 7.37; N, 26.54; O, 4.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AKCI;
IUPAC/Chemical Name
4,8-Dimethyl-N-[3-(2-morpholin-4-ylethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]quinazolin-2-amine
InChi Key
ZUHMBCQGKZNQCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H27N7O/c1-14-4-3-5-16-15(2)22-19(23-17(14)16)24-18-20-12-26(13-21-18)7-6-25-8-10-27-11-9-25/h3-5H,6-13H2,1-2H3,(H2,20,21,22,23,24)
SMILES Code
CC1=CC=CC2=C(C)N=C(NC3=NCN(CCN4CCOCC4)CN3)N=C12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Patthy A, Molnár T, Porrogi P, Naudé R, Gráf L. Isolation and characterization of a protease inhibitor from Acacia karroo with a common combining loop and overlapping binding sites for chymotrypsin and trypsin. Arch Biochem Biophys. 2015 Jan 1;565:9-16. doi: 10.1016/j.abb.2014.11.001. Epub 2014 Nov 8. PubMed PMID: 25447841. 2: Ulu SM, Ahsen A, Akcı Ö, Yaman F, Demir K, Yaman G, Yüksel Ş, Acartürk G. The relationship between dipping-non-dipping arterial blood pressure pattern and frequency of restless leg syndrome with related factors. Anatol J Cardiol. 2015 Apr;15(4):284-8. doi: 10.5152/akd.2014.5381. Epub 2014 Apr 16. PubMed PMID: 25413225; PubMed Central PMCID: PMC5336836. 3: Han EH, Min JY, Yoo SA, Park SJ, Choe YJ, Yun HS, Lee ZW, Jin SW, Kim HG, Jeong HG, Kim HK, Kim ND, Chung YH. A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells. Oncotarget. 2017 Jun 29;8(41):69691-69708. doi: 10.18632/oncotarget.18883. eCollection 2017 Sep 19. PubMed PMID: 29050234; PubMed Central PMCID: PMC5642509.