Cevidoplenib, also known as SKIO703, is am orally active, potent and selective SYK inhibitor with potential anti-inflammatory and immunomodulating activities. Upon oral administration, cevidoplenib binds to and inhibits the activity of SYK, blocking Fc receptor and B-cell receptor (BCR)-mediated signaling in inflammatory cells, including macrophages, neutrophils, mast cells, natural killer (NK) cells and B cells. This leads to the inhibition of the activation of these inflammatory cells, and the related inflammatory responses and tissue damage.
MedKoo Cat#: 561843
Name: Cevidoplenib
CAS#: 1703788-21-9 (free base)
Chemical Formula: C25H27N7O3
Exact Mass: 473.2175
Molecular Weight: 473.53
Elemental Analysis: C, 63.41; H, 5.75; N, 20.71; O, 10.14
The following data is based on the product molecular weight 473.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
