DMPQ dihydrochloride | CAS#1123491-15-5 | PDGFRβ inhibitor

MedKoo Cat#: 341189 | Name: DMPQ dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DMPQ dihydrochloride is a potent selective inhibitor of human vascular beta-type platelet derived growth factor receptor tyrosine kinase (PDGFR?) with IC50 = 80 nM.

Chemical Structure

DMPQ dihydrochloride

CAS#1123491-15-5

Theoretical Analysis

MedKoo Cat#: 341189

Name: DMPQ dihydrochloride

CAS#: 1123491-15-5

Chemical Formula: C16H16Cl2N2O2

Exact Mass: 0.0000

Molecular Weight: 339.22

Elemental Analysis: C, 56.65; H, 4.75; Cl, 20.90; N, 8.26; O, 9.43

Price and Availability

Size	Price	Availability
5mg	USD 250.00	2 Weeks
10mg	USD 450.00	2 Weeks
1g	USD 4,250.00	2 Weeks

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Related CAS #

No Data

Synonym

DMPQ dihydrochloride; DMPQ 2HCl;

IUPAC/Chemical Name

5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

InChi Key

YBBAOKYVJCNJIV-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H

SMILES Code

COC1=CC(OC)=C2C=C(C3=CC=NC=C3)C=NC2=C1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

An potent inhibitor of PDGFRβ.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	PBS (pH 7.2)	10.0	29.48

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 339.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Dolle RE, Dunn JA, Bobko M, Singh B, Kuster JE, Baizman E, Harris AL, Sawutz DG, Miller D, Wang S, et al. 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 1994 Aug 19;37(17):2627-9. doi: 10.1021/jm00043a002. PMID: 8064792.