GNE684 is a RIPK1 inhibitor. GNE684 was shown to be a potent inhibitor of necroptotic cell death in vitro across multiple human and mouse cell lines and also maintained the high RIPK1 specificity of the benzoxazepinone class (S(20) = 0.00) against a 221 kinase panel at 10 μM.
MedKoo Cat#: 122752
Name: GNE684
CAS#: 2438637-64-8
Chemical Formula: C23H24N6O3
Exact Mass: 432.1900
Molecular Weight: 432.48
Elemental Analysis: C, 63.88; H, 5.59; N, 19.43; O, 11.10
The following data is based on the product molecular weight 432.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
