Synonym
MDL72392; MDL 72392; MDL-72392
IUPAC/Chemical Name
Phenol, 3-(1-(aminomethyl)-2-fluoroethenyl)-, (E)-
InChi Key
XFDXQLJFMLWWJA-YVMONPNESA-N
InChi Code
InChI=1S/C9H10FNO/c10-5-8(6-11)7-2-1-3-9(12)4-7/h1-5,12H,6,11H2/b8-5-
SMILES Code
NC\C(=C\F)\c1cccc(O)c1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
167.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Palfreyman MG, McDonald IA, Bey P, Schechter PJ, Sjoerdsma A. Design and early clinical evaluation of selective inhibitors of monoamine oxidase. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):967-87. doi: 10.1016/0278-5846(88)90092-9. PMID: 3266532.
2. Oxenkrug GF, Requintina PJ, Yuwiler A, Palfreyman MG. The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis. J Neural Transm Suppl. 1994;41:377-9. doi: 10.1007/978-3-7091-9324-2_50. PMID: 7931254.
3. Palfreyman MG, Mir AK, Kubina M, Middlemiss DN, Richards M, Tricklebank MD, Fozard JR. Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase. Eur J Pharmacol. 1986 Oct 14;130(1-2):73-89. doi: 10.1016/0014-2999(86)90185-8. PMID: 3780861.
4. Palfreyman MG, McDonald IA, Fozard JR, Mely Y, Sleight AJ, Zreika M, Wagner J, Bey P, Lewis PJ. Inhibition of monoamine oxidase selectively in brain monoamine nerves using the bioprecursor (E)-beta-fluoromethylene-m-tyrosine (MDL 72394), a substrate for aromatic L-amino acid decarboxylase. J Neurochem. 1985 Dec;45(6):1850-60. doi: 10.1111/j.1471-4159.1985.tb10543.x. PMID: 3840523.
5. Fagervall I, Ross SB. Inhibition of monoamine oxidase within monoaminergic neurons in the rat brain by (E)-beta-fluoromethylene-m-tyrosine (MDL 72394). J Neurochem. 1989 Feb;52(2):467-71. doi: 10.1111/j.1471-4159.1989.tb09144.x. PMID: 2521360.
