R(-)-alpha-Methylhistamine 2HCl | CAS#75614-89-0 | H3 histamine receptor agonist

MedKoo Cat#: 527795 | Name: R(-)-alpha-Methylhistamine 2HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R(-)-alpha-Methylhistamine 2HCl is a potent, selective H3 histamine receptor agonist, crossing the blood-brain barrier and inhibiting histamine synthesis and release.

Chemical Structure

R(-)-alpha-Methylhistamine 2HCl

CAS#75614-89-0

Theoretical Analysis

MedKoo Cat#: 527795

Name: R(-)-alpha-Methylhistamine 2HCl

CAS#: 75614-89-0

Chemical Formula: C6H13Cl2N3

Exact Mass: 197.0487

Molecular Weight: 198.09

Elemental Analysis: C, 36.38; H, 6.62; Cl, 35.79; N, 21.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

R(-)-alpha-Methylhistamine 2HCl

IUPAC/Chemical Name

R(-)-a-Methyl-1H-imidazole-4-ethanamine dihydrochloride

InChi Key

IZHCNQFUWDFPCW-ZJIMSODOSA-N

InChi Code

InChI=1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1

SMILES Code

N[C@H](C)CC1=CNC=N1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 198.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lamberti C, Bartolini A, Ghelardini C, Malmberg-Aiello P. Investigation into the role of histamine receptors in rodent antinociception. Pharmacol Biochem Behav. 1996 Mar;53(3):567-74. PubMed PMID: 8866956. 2: Malmberg-Aiello P, Lamberti C, Ghelardini C, Giotti A, Bartolini A. Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr;111(4):1269-79. PubMed PMID: 8032614; PubMed Central PMCID: PMC1910136.