SYR127063, also known as BDBM92454, is a potent and selective HER2 inhibitor (IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM). SYR127063 binds to HER2 in an active-like conformation.
MedKoo Cat#: 407332
Name: SYR127063
CAS#: 871026-18-5
Chemical Formula: C23H20ClF3N4O3
Exact Mass: 492.1176
Molecular Weight: 492.88
Elemental Analysis: C, 56.05; H, 4.09; Cl, 7.19; F, 11.56; N, 11.37; O, 9.74
The following data is based on the product molecular weight 492.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
