MedKoo Cat#: 562310 | Name: Molindone HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Molindone HCl is a D2 dopamine receptor antagonist. It also acts as a MAO inhibitor.

Chemical Structure

Molindone HCl
Molindone HCl
CAS#15622-65-8

Theoretical Analysis

MedKoo Cat#: 562310

Name: Molindone HCl

CAS#: 15622-65-8

Chemical Formula: C16H25ClN2O2

Exact Mass: 312.1605

Molecular Weight: 312.84

Elemental Analysis: C, 61.43; H, 8.06; Cl, 11.33; N, 8.95; O, 10.23

Price and Availability

Size Price Availability Quantity
10mg USD 330.00
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Synonym
Molindone HCl; Molindone Hydrochloride; Molindone Hydrochloride salt; Molindone HCl salt; Moban;
IUPAC/Chemical Name
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one hydrochloride
InChi Key
GQWNECFJGBQMBO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H
SMILES Code
O=C1C2=C(NC(C)=C2CC)CCC1CN3CCOCC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.
In vitro activity:
TBD
In vivo activity:
The present study assessed changes of tryptamine, dopamine D2, 5-HT1 and 5-HT2 binding sites in rat brain following chronic treatment with low (5 mg/kg/day) and high (40 mg/kg/day) doses of molindone, a clinically effective psychotropic drug. The high-dose molindone treatment produced a decrease in the number of tryptamine binding sites while both high and low doses caused an increase in the number of dopamine D2 binding sites in the striatum. Competition binding experiments showed that molindone was a potent inhibitor at dopamine D2 but less effective at tryptamine, 5-HT1 and 5-HT2 binding sites. The inhibition activity of molindone towards type A monoamine oxidase produced a significant increase in endogenous tryptamine accumulation rate which was much higher than that of dopamine and 5-HT. Reference: Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):366-71. https://pubmed.ncbi.nlm.nih.gov/2586632/
Solvent mg/mL mM
Solubility
DMF 2.0 6.39
DMSO 9.5 30.37
Ethanol 2.0 6.39
PBS (pH 7.2) 10.0 31.97
Water 100.0 319.65
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 312.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Nguyen TV, Juorio AV. Down-regulation of tryptamine binding sites following chronic molindone administration. A comparison with responses of dopamine and 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):366-71. doi: 10.1007/BF00167036. PMID: 2586632.
In vitro protocol:
TBD
In vivo protocol:
Nguyen TV, Juorio AV. Down-regulation of tryptamine binding sites following chronic molindone administration. A comparison with responses of dopamine and 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):366-71. doi: 10.1007/BF00167036. PMID: 2586632.
1: Olson GL, Cheung HC, Morgan KD, Blount JF, Todaro L, Berger L, Davidson AB, Boff E. A dopamine receptor model and its application in the design of a new class of rigid pyrrolo[2,3-g]isoquinoline antipsychotics. J Med Chem. 1981 Sep;24(9):1026-34. PubMed PMID: 6116805. 2: Kellner R, Gervais RH, Pathak D. A pilot study of the short-term antianxiety effects of molindone HCl. J Clin Pharmacol New Drugs. 1972 Nov-Dec;12(11):472-6. PubMed PMID: 4563663.