Synonym
YM 16638; YM-16638; YM16638.
IUPAC/Chemical Name
Acetic acid, ((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)-
InChi Key
RRUNJEUMTFLLDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22N2O5S3/c1-3-5-13-14(7-6-12(11(2)21)16(13)24)25-8-4-9-26-17-19-20-18(28-17)27-10-15(22)23/h6-7,24H,3-5,8-10H2,1-2H3,(H,22,23)
SMILES Code
C(CSc1sc(nn1)SCCCOc1c(c(c(cc1)C(=O)C)O)CCC)(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
442.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tohda Y. [My research on asthma today and in the future]. Arerugi. 2013 Nov;62(11):1501-14. Review. Japanese. PubMed PMID: 24552761.
2: Goto S, Shimokawa T. Effect of the hypocholesterolemic agent YM-16638 on cholesterol biosynthesis activity and apolipoprotein B secretion in HepG2 and monkey liver. Jpn J Pharmacol. 1999 Jan;79(1):75-82. PubMed PMID: 10082320.
3: Goto S, Shimokawa T, Ugawa T, Hisamichi N, Masuyama Y, Iizumi Y, Sato N, Takenaka T, Kodama T. Species specificity in the blood cholesterol-lowering effect of YM-16638. Br J Pharmacol. 1996 May;118(1):174-8. PubMed PMID: 8733592; PubMed Central PMCID: PMC1909480.
4: Miyata K, Kamato T, Nishida A, Takizawa K, Takeda M. Gastric mucosal protection by YM638, a novel leukotriene D4 receptor antagonist, in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):165-75. PubMed PMID: 7781686.
5: Kobayashi K, Fukuda T, Higuchi K, Nakamura H, Arakawa T. Role of leukotrienes in indomethacin-induced mucosal damage in rats. J Clin Gastroenterol. 1993;17 Suppl 1:S11-4. PubMed PMID: 8283004.
6: Yoshikawa T, Ichikawa H, Naito Y, Kondo M. Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats. J Clin Gastroenterol. 1992;14 Suppl 1:S68-70. PubMed PMID: 1629580.
7: Filep JG, Battistini B, Sirois P. Pharmacological modulation of endothelin-induced contraction of guinea-pig isolated airways and thromboxane release. Br J Pharmacol. 1991 Jul;103(3):1633-40. PubMed PMID: 1933129; PubMed Central PMCID: PMC1907823.
8: Tomioka K, Jackowski JT, Abraham WM. Characterization of sulfidopeptide leukotriene responses in sheep tracheal smooth muscle in vitro. Can J Physiol Pharmacol. 1991 Jun;69(6):805-11. PubMed PMID: 1655181.
9: Osada T, Goto H, Tsukamoto Y, Nakazawa S, Sugiyama S, Ozawa T. Role of leukotrienes in hydrochloric acid-induced gastric lesions in rats. Dig Dis Sci. 1990 Feb;35(2):186-92. PubMed PMID: 2105876.
10: Tomioka K, Garrido R, Stevenson JS, Abraham WM. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. PubMed PMID: 2740413.
11: Tomioka K, Yamada T, Mase T, Hara H, Murase K. Pharmacological properties of the orally active leukotriene antagonist [[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]thio]-1,3,4- thiadiazol-2-yl]thio]acetic acid. Arzneimittelforschung. 1988 May;38(5):682-5. PubMed PMID: 3415708.
