ZM323881 HCl | CAS#324077-30-7 | 193000-39-4 | VEGFR inhibitor

MedKoo Cat#: 405610 | Name: ZM323881 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50) > 50 microM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro.

Chemical Structure

ZM323881 HCl

CAS#193000-39-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 405610

Name: ZM323881 HCl

CAS#: 193000-39-4 (HCl)

Chemical Formula: C22H19ClFN3O2

Exact Mass: 375.1383

Molecular Weight: 411.12

Elemental Analysis: C, 64.16; H, 4.65; Cl, 8.61; F, 4.61; N, 10.20; O, 7.77

Price and Availability

Size	Price	Availability
5mg	USD 325.00	2 Weeks
25mg	USD 750.00	2 Weeks
50mg	USD 1,050.00	2 Weeks
100mg	USD 1,650.00	2 Weeks

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Related CAS #

324077-30-7 (free base) 193000-39-4 (HCl)

Synonym

ZM323881; ZM 323881; ZM-323881; ZM323881 HCl; ZM323881 hydrochloride

IUPAC/Chemical Name

5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride

InChi Key

AVRHWGLIYGJSOD-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H

SMILES Code

OC1=CC(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)=C(F)C=C1C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years

Solubility

Soluble in DMSO, not in water

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 324077-30-7 ( ZM323881 free base) 193000-39-4 ( ZM323881 HCl).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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