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MedKoo Cat#: 562281 | Name: TGN-020
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TGN-020 is an aquaporin 4 (AQP4) channel blocker. It acts by increasing regional cerebral blood flow and reducing ischemia-induced brain edema.

Chemical Structure

TGN-020
TGN-020
CAS#51987-99-6 (free base)

Theoretical Analysis

MedKoo Cat#: 562281

Name: TGN-020

CAS#: 51987-99-6 (free base)

Chemical Formula: C8H6N4OS

Exact Mass: 206.0262

Molecular Weight: 206.22

Elemental Analysis: C, 46.59; H, 2.93; N, 27.17; O, 7.76; S, 15.55

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
100mg USD 400.00 2 Weeks
200mg USD 650.00 2 Weeks
500mg USD 1,250.00 2 Weeks
1g USD 1,850.00 2 Weeks
2g USD 2,850.00 2 Weeks
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Related CAS #
1313731-99-5 (sodium) 51987-99-6 (free base)
Synonym
TGN-020; TGN 020; TGN020;
IUPAC/Chemical Name
N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
InChi Key
AGEGZHOPKZFKBP-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
SMILES Code
O=C(C1=CC=CN=C1)NC2=NN=CS2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 206.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen W, Liang C, Peng S, Bao S, Xue F, Lian X, Liu Y, Wang G. Aquaporin-4 activation facilitates glymphatic system function and hematoma clearance post- intracerebral hemorrhage. Glia. 2025 Feb;73(2):368-380. doi: 10.1002/glia.24639. Epub 2024 Nov 12. PMID: 39530196; PMCID: PMC11662979. 2: Zhang Y, Wu L, He K, Cheng Y, Li L, Han D. Electroacupuncture alleviated chronic cerebral hypoperfusion damages via targeting aquaporin 4 to prevent amyloid-beta accumulation. Neuroreport. 2025 Jan 8;36(1):11-21. doi: 10.1097/WNR.0000000000002114. Epub 2024 Nov 12. PMID: 39526677. 3: Xing X, Zhang S. Neuroprotective Role of AQP4 Knockdown in Astrocytes After Oxygen-Glucose Deprivation. Brain Behav. 2024 Oct;14(10):e70107. doi: 10.1002/brb3.70107. PMID: 39444081; PMCID: PMC11499208. 4: Gomez FD, Reppetti J, Alvarez RS, Girón Reyes DC, Sacerdoti F, Balestracci A, Damiano AE, Martínez NA, Di Giusto G, Amaral MM. Involvement of aquaporins in Shiga toxin-induced swelling and water transport dysfunction in human renal microvascular endothelial cells. Biochim Biophys Acta Mol Cell Res. 2025 Jan;1872(1):119866. doi: 10.1016/j.bbamcr.2024.119866. Epub 2024 Oct 21. PMID: 39442808. 5: Kong J, Zhang Q, Zheng H, Tang D, Fang L, An S, Li J, Fan Z. Corrigendum to "TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway" [Experimental Neurology volume 382 (2024) 114975]. Exp Neurol. 2025 Jan;383:114998. doi: 10.1016/j.expneurol.2024.114998. Epub 2024 Oct 20. Erratum for: Exp Neurol. 2024 Dec;382:114975. doi: 10.1016/j.expneurol.2024.114975. PMID: 39428307. 6: Kong J, Zhang Q, Zheng H, Tang D, Fang L, An S, Li J, Fan Z. TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway. Exp Neurol. 2024 Dec;382:114975. doi: 10.1016/j.expneurol.2024.114975. Epub 2024 Sep 24. Erratum in: Exp Neurol. 2025 Jan;383:114998. doi: 10.1016/j.expneurol.2024.114998. PMID: 39326822. 7: Nie FY, Jin RY, Wu SS, Yuan W, Wu YW, Xue SM, Yang XH, Qiao HF. AQP4 is upregulated in schizophrenia and Its inhibition attenuates MK-801-induced schizophrenia-like behaviors in mice. Behav Brain Res. 2024 Oct 18;475:115220. doi: 10.1016/j.bbr.2024.115220. Epub 2024 Aug 28. PMID: 39214422. 8: Mo S, Yang C, Zheng X, Lv H, Mao S, Liu N, Yang Q, Liao B, Yang M, Lu Z, Tang L, Huang X, Jian C, Li X, Shang J. Neuroprotective Effects of AER-271 in a tMCAO Mouse Model: Modulation of Autophagy, Apoptosis, and Inflammation. Inflammation. 2024 Aug 9. doi: 10.1007/s10753-024-02082-7. Epub ahead of print. PMID: 39117789. 9: Peng W, Yuan Y, Lei J, Zhao Y, Li Y, Qu Q, Wang J. Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta. Mol Neurobiol. 2024 Jul 3. doi: 10.1007/s12035-024-04320-3. Epub ahead of print. PMID: 38958889. 10: Wang Z, Xue F, Zhang J, Wang Y, Hu E, Zheng Y, Luo X, Li H, Qiao B. The cornel Iridoid glycoside attenuated brain edema of the cerebral ischemia/reperfusion rats by modulating the polarized aquaporin 4. Fitoterapia. 2024 Sep;177:106098. doi: 10.1016/j.fitote.2024.106098. Epub 2024 Jun 29. PMID: 38950636. 11: Lopes DM, Wells JA, Ma D, Wallis L, Park D, Llewellyn SK, Ahmed Z, Lythgoe MF, Harrison IF. Glymphatic inhibition exacerbates tau propagation in an Alzheimer's disease model. Alzheimers Res Ther. 2024 Apr 5;16(1):71. doi: 10.1186/s13195-024-01439-2. Erratum in: Alzheimers Res Ther. 2024 Nov 28;16(1):258. doi: 10.1186/s13195-024-01624-3. PMID: 38576025; PMCID: PMC10996277. 12: Rostami F, Jaafari Suha A, Janahmadi M, Hosseinmardi N. Aquaporin-4 inhibition attenuates Pentylenetetrazole-induced behavioral seizures and cognitive impairments in kindled rats. Physiol Behav. 2024 May 1;278:114521. doi: 10.1016/j.physbeh.2024.114521. Epub 2024 Mar 14. PMID: 38492911. 13: Dong R, Han Y, Lv P, Jiang L, Wang Z, Peng L, Liu S, Ma Z, Xia T, Zhang B, Gu X. Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance. J Cereb Blood Flow Metab. 2024 Aug;44(8):1450-1466. doi: 10.1177/0271678X241237073. Epub 2024 Mar 5. PMID: 38443763; PMCID: PMC11342724. 14: Thormann M, Traube N, Yehia N, Koestler R, Galabova G, MacAulay N, Toft- Bertelsen TL. Toward New AQP4 Inhibitors: ORI-TRN-002. Int J Mol Sci. 2024 Jan 11;25(2):924. doi: 10.3390/ijms25020924. PMID: 38255997; PMCID: PMC10815436. 15: Song Y, Xue T, Guo S, Yu Z, Yun C, Zhao J, Song Z, Liu Z. Inhibition of aquaporin-4 and its subcellular localization attenuates below-level central neuropathic pain by regulating astrocyte activation in a rat spinal cord injury model. Neurotherapeutics. 2024 Mar;21(2):e00306. doi: 10.1016/j.neurot.2023.e00306. Epub 2023 Dec 19. PMID: 38237380; PMCID: PMC10963936. 16: Chen Z, Lai JHC, Xu J, Zhang H, Huang J, Chan KWY. The effect of aquaporin-4 inhibition on cerebrospinal fluid-tissue water exchange in mouse brain detected by magnetization transfer indirect spin labeling MRI. NMR Biomed. 2024 Jul;37(7):e5093. doi: 10.1002/nbm.5093. Epub 2024 Jan 1. PMID: 38163739. 17: He R, Zhang X, Pang C, Lin L, Li S, Jin L, Ding L, Wang W. Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating aquaporin-4 after traumatic brain injury in mice. Heliyon. 2023 Nov 13;9(11):e22035. doi: 10.1016/j.heliyon.2023.e22035. PMID: 38053850; PMCID: PMC10694165. 18: Khan S, Lokman NA, Oehler MK, Ricciardelli C, Yool AJ. Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers (Basel). 2023 Sep 11;15(18):4507. doi: 10.3390/cancers15184507. PMID: 37760476; PMCID: PMC10526386. 19: Li X, Xie Z, Zhou Q, Tan X, Meng W, Pang Y, Huang L, Ding Z, Hu Y, Li R, Huang G, Li H. TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia-Reperfusion Injury in Mice Through Glymphatic and ERK1/2 Signaling Pathway. Mol Neurobiol. 2024 Feb;61(2):1175-1186. doi: 10.1007/s12035-023-03636-w. Epub 2023 Sep 11. PMID: 37695472; PMCID: PMC10861636. 20: Huang W, Zhang Y, Zhou Y, Zong J, Qiu T, Hu L, Pan S, Xiao Z. Glymphatic Dysfunction in Migraine Mice Model. Neuroscience. 2023 Sep 15;528:64-74. doi: 10.1016/j.neuroscience.2023.07.027. Epub 2023 Jul 28. PMID: 37516436.