4-piperidinecarboxylic acid, also known as pomalidomide-piperidine-carboxylic acid, is a ProTAC building block. 4-piperidinecarboxylic acid is a functionalized cereblon ligand for the development of pomalidomide-based ProTACs. It allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions.
MedKoo Cat#: 121154
Name: 4-Piperidinecarboxylic acid
CAS#: 2467965-70-2
Chemical Formula: C19H19N3O6
Exact Mass: 385.1274
Molecular Weight: 385.38
Elemental Analysis: C, 59.22; H, 4.97; N, 10.90; O, 24.91
The following data is based on the product molecular weight 385.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
