MedKoo Cat#: 584361 | Name: Cyheptamide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyheptamide is an anticonvulsant.

Chemical Structure

Cyheptamide
Cyheptamide
CAS#7199-29-3

Theoretical Analysis

MedKoo Cat#: 584361

Name: Cyheptamide

CAS#: 7199-29-3

Chemical Formula: C16H15NO

Exact Mass: 237.1154

Molecular Weight: 237.30

Elemental Analysis: C, 80.98; H, 6.37; N, 5.90; O, 6.74

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Cyheptamide; AY 8682; AY-8682; AY8682;
IUPAC/Chemical Name
10,11-Dihydro-5H-dibenzocycloheptene-5-carboxamide
InChi Key
ADPMNZUPGYNXCQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15NO/c17-16(18)15-10-9-11-5-1-2-6-12(11)13-7-3-4-8-14(13)15/h1,3-5,7-10,15H,2,6H2,(H2,17,18)
SMILES Code
O=C(C1C=CC(C=CCC2)=C2C3=CC=CC=C31)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: van Eeken CJ, Birtwhistle RD, Mulder D. Toxicological study of cyheptamide: 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxamide (BS 7029). Arch Int Pharmacodyn Ther. 1970 Nov;188(1):79-85. PubMed PMID: 5485105. 2: Codding PW, Lee TA, Richardson JF. Cyheptamide and 3-hydroxy-3-phenacyloxindole: structural similarity to diphenylhydantoin as the basis for anticonvulsant activity. J Med Chem. 1984 May;27(5):649-54. PubMed PMID: 6716403. 3: Kraml M, Sestanj K, Dvornik D. Metabolism of the anticonvulsant 10,11-dihydro-5H-dibenzo(a,d)cycloheptene-5-carboxamide. I. Metabolic fate of (14C)cyheptamide in animals and man. Biochem Pharmacol. 1971 Sep;20(9):2327-38. PubMed PMID: 5163146. 4: Conway JM, Birnbaum AK, Marino SE, Cloyd JC, Remmel RP. A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies. Biomed Chromatogr. 2012 Sep;26(9):1071-6. doi: 10.1002/bmc.1749. Epub 2012 Jan 4. PubMed PMID: 22223467; PubMed Central PMCID: PMC3776594. 5: Jones GL, Amato RJ, Wimbish GH, Peyton GA. Comparison of anticonvulsant potencies of cyheptamide, carbamazepine, and phenytoin. J Pharm Sci. 1981 Jun;70(6):618-20. PubMed PMID: 7252802. 6: Paglia G, D'Apolito O, Garofalo D, Scarano C, Corso G. Development and validation of a LC/MS/MS method for simultaneous quantification of oxcarbazepine and its main metabolites in human serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 15;860(2):153-9. Epub 2007 Oct 25. PubMed PMID: 17996501. 7: Srirambhatla VK, Guo R, Price SL, Florence AJ. Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs. Chem Commun (Camb). 2016 May 31;52(46):7384-6. doi: 10.1039/c6cc01710j. PubMed PMID: 27193234. 8: Jones GL, Amato RJ, Jones MF. alpha,alpha-Diphenylsuccinimide: evaluation of anticonvulsant and hydrophobic properties. J Pharm Sci. 1984 Mar;73(3):310-3. PubMed PMID: 6716236. 9: Cham BE, Sadowski B, O'Hagan JM, de Wytt CN, Bochner F, Eadie MJ. High performance liquid chromatographic assay of dexamethasone in plasma and tissue. Ther Drug Monit. 1980;2(4):373-7. PubMed PMID: 7222192. 10: Lensmeyer GL, Gidal BE, Wiebe DA. Optimized high-performance liquid chromatographic method for determination of lamotrigine in serum with concomitant determination of phenytoin, carbamazepine, and carbamazepine epoxide. Ther Drug Monit. 1997 Jun;19(3):292-300. PubMed PMID: 9200770. 11: Sheehan M, Haythorn P. Rapid gas chromatographic determination of underivatized theophylline in whole blood. J Chromatogr. 1976 Feb 18;117(2):392-8. PubMed PMID: 2615. 12: Soldin SJ, Hill JG. Rapid micromethod for measuring anticonvulsant drugs in serum by high-performance liquid chromatography. Clin Chem. 1976 Jun;22(6):856-9. PubMed PMID: 1277473. 13: Saavedra I, Pavani M, Estruch J, Galdámes D, Leyton S. [Determination of plasma lidocaine by gas-liquid chromatography]. Rev Med Chil. 1987 Jul;115(7):661-4. Spanish. PubMed PMID: 3453531. 14: Wimbish GH, Jones GL, Amato RJ, Peyton GA. Anticonvulsant activities and brain concentrations of cyheptamide and carbamazepine. Proc West Pharmacol Soc. 1980;23:75-9. PubMed PMID: 7403169. 15: Funcke AB, van Beek MC, van Hell G, Lavy UI, Timmerman H, Zandberg P. Cyheptamide. A pharmacological evaluation. Arch Int Pharmacodyn Ther. 1970 Sep;187(1):174-91. PubMed PMID: 4394698. 16: Kraml M, Dvornik D, Cosyns L. Colorimetric determination of C-10 hydroxylated metabolites of cyheptamide: application to absorption and enzyme induction studies in the rat. J Pharm Sci. 1972 Mar;61(3):408-12. PubMed PMID: 5013378. 17: Doorenbos HJ, de Jonge H, Corts GJ, Nauta WT. Investigation of cyheptamide, 10,11-dihydro-5H-dibenzo [a,d]cycloheptene-5-carboxamide (BS 7029). Pharm Weekbl. 1969 Jun 27;104(26):732-7. PubMed PMID: 5789020.