L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor that depletes glutathione levels by inhibiting synthesis. L-Buthionine sulfoximine also induces ferroptosis in vitro.
MedKoo Cat#: 574070
Name: L-Buthionine sulfoximine
CAS#: 83730-53-4 (L)
Chemical Formula: C8H18N2O3S
Exact Mass: 222.1038
Molecular Weight: 222.30
Elemental Analysis: C, 43.22; H, 8.16; N, 12.60; O, 21.59; S, 14.42
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.2 | 100.00 | |
| PBS (pH 7.2) | 5.0 | 22.49 | |
| Water | 26.9 | 120.80 |
The following data is based on the product molecular weight 222.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
