Cevoglitazar | CAS#839673-52-8 | PPARγ agonist

MedKoo Cat#: 328077 | Name: Cevoglitazar

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cevoglitazar, also known as LBM-642, is a PPARɑ agonist and PPARγ agonist potentially for the treatment of type 2 diabetes and lipid metabolism. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys. Cevoglitazar was as effective as pioglitazone at improving glucose tolerance.

Chemical Structure

Cevoglitazar

CAS#839673-52-8

Theoretical Analysis

MedKoo Cat#: 328077

Name: Cevoglitazar

CAS#: 839673-52-8

Chemical Formula: C27H21F3N2O6S

Exact Mass: 558.1072

Molecular Weight: 558.53

Elemental Analysis: C, 58.06; H, 3.79; F, 10.20; N, 5.02; O, 17.19; S, 5.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Cevoglitazar; LBM-642; LBM 642; LBM642.

IUPAC/Chemical Name

(R)-1-((4-((5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methoxy)phenyl)sulfonyl)indoline-2-carboxylic acid

InChi Key

KVVODNUBDFULSC-XMMPIXPASA-N

InChi Code

InChI=1S/C27H21F3N2O6S/c1-16-22(31-25(38-16)17-6-8-19(9-7-17)27(28,29)30)15-37-20-10-12-21(13-11-20)39(35,36)32-23-5-3-2-4-18(23)14-24(32)26(33)34/h2-13,24H,14-15H2,1H3,(H,33,34)/t24-/m1/s1

SMILES Code

O=C([C@@H]1N(S(=O)(C2=CC=C(OCC3=C(C)OC(C4=CC=C(C(F)(F)F)C=C4)=N3)C=C2)=O)C5=C(C=CC=C5)C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 558.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen H, Dardik B, Qiu L, Ren X, Caplan SL, Burkey B, Boettcher BR, Gromada J. Cevoglitazar, a novel peroxisome proliferator-activated receptor-alpha/gamma dual agonist, potently reduces food intake and body weight in obese mice and cynomolgus monkeys. Endocrinology. 2010 Jul;151(7):3115-24. doi: 10.1210/en.2009-1366. PubMed PMID: 20484464. 2: Laurent D, Gounarides JS, Gao J, Boettcher BR. Effects of cevoglitazar, a dual PPARalpha/gamma agonist, on ectopic fat deposition in fatty Zucker rats. Diabetes Obes Metab. 2009 Jun;11(6):632-6. doi: 10.1111/j.1463-1326.2008.01017.x. PubMed PMID: 19175377.