MedKoo Cat#: 581088 | Name: Deudextromethorphan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deudextromethorphan is also known as AVP-786. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type.

Chemical Structure

Deudextromethorphan
Deudextromethorphan
CAS#1079043-55-2 (free base)

Theoretical Analysis

MedKoo Cat#: 581088

Name: Deudextromethorphan

CAS#: 1079043-55-2 (free base)

Chemical Formula: C18H19D6NO

Exact Mass: 277.2313

Molecular Weight: 277.44

Elemental Analysis: C, 77.93; H, 11.26; N, 5.05; O, 5.77

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
125-69-9 (HBr) 125-71-3 (free base) 18609-21-7 (HCl) 6700-34-1 (HBr hydrate) 1373497-18-7 (d6 HBr hydrate) 1079043-55-2 (free base)
Synonym
Deudextromethorphan; CTP-786; D6-Dextromethorphan; d6-DM; AVP-786;
IUPAC/Chemical Name
Morphinan, 3-(methoxy-D3)-17-(methyl-D3)-, (9alpha,13alpha,14alpha)-
InChi Key
MKXZASYAUGDDCJ-QNNIAVNKSA-N
InChi Code
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1/i1D3,2D3
SMILES Code
[2H]C([2H])(Oc1cc2c(C[C@H]3[C@H]4CCCC[C@]42CCN3C([2H])([2H])[2H])cc1)[2H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garay RP, Grossberg GT. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132. doi: 10.1080/13543784.2017.1267726. Epub 2016 Dec 11. Review. PubMed PMID: 27936965. 2: Garay RP, Citrome L, Grossberg GT, Cavero I, Llorca PM. Investigational drugs for treating agitation in persons with dementia. Expert Opin Investig Drugs. 2016 Aug;25(8):973-83. doi: 10.1080/13543784.2016.1193155. Epub 2016 Jun 7. Review. PubMed PMID: 27232589. 3: Garay RP, Zarate CA Jr, Charpeaud T, Citrome L, Correll CU, Hameg A, Llorca PM. Investigational drugs in recent clinical trials for treatment-resistant depression. Expert Rev Neurother. 2017 Jun;17(6):593-609. doi: 10.1080/14737175.2017.1283217. Epub 2017 Jan 29. Review. PubMed PMID: 28092469; PubMed Central PMCID: PMC5418088. 4: Henter ID, de Sousa RT, Zarate CA Jr.. Glutamatergic Modulators in Depression. Harv Rev Psychiatry. 2018 Feb 20. doi: 10.1097/HRP.0000000000000183. [Epub ahead of print] PubMed PMID: 29465478. 5: Javelot H. [Psychopharmacology of anxiety and depression: Historical aspects, current treatments and perspectives]. Ann Pharm Fr. 2016 Mar;74(2):93-118. doi: 10.1016/j.pharma.2015.09.001. Epub 2015 Oct 16. Review. French. PubMed PMID: 26472602.