MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 329660 | Name: Dextromethorphan HBr hydrate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dextromethorphan (DXM), is a cough suppressant used in many cough and cold medicines. It affects serotonin, norepinephrine, NMDA, and sigma-1 receptors in the brain, all of which have been implicated in the pathophysiology of depression. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors.

Chemical Structure

Dextromethorphan HBr hydrate
Dextromethorphan HBr hydrate
CAS#6700-34-1 (HBr hydrate)

Theoretical Analysis

MedKoo Cat#: 329660

Name: Dextromethorphan HBr hydrate

CAS#: 6700-34-1 (HBr hydrate)

Chemical Formula: C18H28BrNO2

Exact Mass: 0.0000

Molecular Weight: 370.33

Elemental Analysis: C, 58.38; H, 7.62; Br, 21.58; N, 3.78; O, 8.64

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 450.00 2 Weeks
5g USD 750.00 2 Weeks
10g USD 1,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
125-69-9 (HBr) 125-71-3 (free base) 18609-21-7 (HCl) 6700-34-1 (HBr hydrate)
Synonym
Dextromethorphan HBr; Ro 1-5470/5; Romilar; Romilar hydrobromide; Tusilan; Tussade;
IUPAC/Chemical Name
(4bS,8aS,9S)-3-methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene hydrobromide hydrate
InChi Key
STTADZBLEUMJRG-IKNOHUQMSA-N
InChi Code
InChI=1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1
SMILES Code
CN1CC[C@]23C4=CC(OC)=CC=C4C[C@@]1([H])[C@@]2([H])CCCC3.[H]Br.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 370.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer's disease. Expert Opin Pharmacother. 2017 Apr;18(6):611-620. doi: 10.1080/14656566.2017.1307340. Epub 2017 Mar 28. Review. PubMed PMID: 28300462. 2: Lener MS, Kadriu B, Zarate CA Jr. Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression. Drugs. 2017 Mar;77(4):381-401. doi: 10.1007/s40265-017-0702-8. Review. PubMed PMID: 28194724; PubMed Central PMCID: PMC5342919. 3: Garay RP, Grossberg GT. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132. doi: 10.1080/13543784.2017.1267726. Epub 2016 Dec 11. Review. PubMed PMID: 27936965. 4: Alviar MJ, Hale T, Dungca M. Pharmacologic interventions for treating phantom limb pain. Cochrane Database Syst Rev. 2016 Oct 14;10:CD006380. Review. PubMed PMID: 27737513. 5: Shuying L, Ping L, Juan N, Dong L. Different interventions in preventing opioid-induced cough: a meta-analysis. J Clin Anesth. 2016 Nov;34:440-7. doi: 10.1016/j.jclinane.2016.05.034. Epub 2016 Jun 17. Review. PubMed PMID: 27687431. 6: Storck M, Black L, Liddell M. Inhalant Abuse and Dextromethorphan. Child Adolesc Psychiatr Clin N Am. 2016 Jul;25(3):497-508. doi: 10.1016/j.chc.2016.03.007. Review. PubMed PMID: 27338970. 7: Eggleston W, Stork C. Generation Z: Adolescent Xenobiotic Abuse in the 21st Century. Adolesc Med State Art Rev. 2015 Dec;26(3):570-88. Review. PubMed PMID: 27282013. 8: Garay RP, Citrome L, Grossberg GT, Cavero I, Llorca PM. Investigational drugs for treating agitation in persons with dementia. Expert Opin Investig Drugs. 2016 Aug;25(8):973-83. doi: 10.1080/13543784.2016.1193155. Epub 2016 Jun 7. Review. PubMed PMID: 27232589. 9: Taylor CP, Traynelis SF, Siffert J, Pope LE, Matsumoto RR. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use. Pharmacol Ther. 2016 Aug;164:170-82. doi: 10.1016/j.pharmthera.2016.04.010. Epub 2016 Apr 29. Review. PubMed PMID: 27139517. 10: Koskela H, Naaranlahti T. [Drug therapy for cough]. Duodecim. 2016;132(5):455-60. Review. Finnish. PubMed PMID: 27089619. 11: Lauterbach EC. Repurposing psychiatric medicines to target activated microglia in anxious mild cognitive impairment and early Parkinson's disease. Am J Neurodegener Dis. 2016 Mar 1;5(1):29-51. eCollection 2016. Review. PubMed PMID: 27073741; PubMed Central PMCID: PMC4788730. 12: Jaso BA, Niciu MJ, Iadarola ND, Lally N, Richards EM, Park M, Ballard ED, Nugent AC, Machado-Vieira R, Zarate CA. Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder. Curr Neuropharmacol. 2017;15(1):57-70. Review. PubMed PMID: 26997505; PubMed Central PMCID: PMC5327449. 13: He ZX, Chen XW, Yang Y, Zhou SF. A Comparison of Non-Human Primate Cytochrome P450 2D Members and the Implication in Drug Discovery. Curr Drug Metab. 2016;17(6):520-7. Review. PubMed PMID: 26892731. 14: Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacol Ther. 2016 Mar;159:1-22. doi: 10.1016/j.pharmthera.2016.01.016. Epub 2016 Jan 28. Review. PubMed PMID: 26826604. 15: Machado-Vieira R, Henter ID, Zarate CA Jr. New targets for rapid antidepressant action. Prog Neurobiol. 2017 May;152:21-37. doi: 10.1016/j.pneurobio.2015.12.001. Epub 2015 Dec 23. Review. PubMed PMID: 26724279; PubMed Central PMCID: PMC4919246. 16: Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Vet J. 2016 Jan;207:29-37. doi: 10.1016/j.tvjl.2015.09.016. Epub 2015 Sep 16. Review. PubMed PMID: 26586215. 17: Dimitrakopoulos S, Konstantakopoulos G. Pharmacological agents under research for the maintenance treatment in bipolar disorder. Psychiatriki. 2015 Jul-Sep;26(3):169-80. Review. PubMed PMID: 26480221. 18: Panza F, Solfrizzi V, Seripa D, Imbimbo BP, Santamato A, Lozupone M, Prete C, Greco A, Pilotto A, Logroscino G. Progresses in treating agitation: a major clinical challenge in Alzheimer's disease. Expert Opin Pharmacother. 2015;16(17):2581-8. doi: 10.1517/14656566.2015.1092520. Epub 2015 Sep 21. Review. PubMed PMID: 26389682. 19: Antonsdottir IM, Smith J, Keltz M, Porsteinsson AP. Advancements in the treatment of agitation in Alzheimer's disease. Expert Opin Pharmacother. 2015;16(11):1649-56. doi: 10.1517/14656566.2015.1059422. Review. PubMed PMID: 26159445. 20: Thapliyal N, Patel H, Karpoormath R, Goyal RN, Patel R. A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs. Talanta. 2015 Sep 1;142:157-63. doi: 10.1016/j.talanta.2015.04.061. Epub 2015 Apr 29. Review. PubMed PMID: 26003706.