MedKoo Cat#: 581082 | Name: Benzoxonium chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy. the topical use of Thio-Ben combined with cryotherapy has a good efficacy in treating ACL with the benefit that Thio-Ben has more patient compliance and less side effects than intralesional Glucantime.

Chemical Structure

Benzoxonium chloride
CAS#19379-90-9 (chloride)

Theoretical Analysis

MedKoo Cat#: 581082

Name: Benzoxonium chloride

CAS#: 19379-90-9 (chloride)

Chemical Formula: C23H42ClNO2

Exact Mass: 399.2904

Molecular Weight: 400.04

Elemental Analysis: C, 69.06; H, 10.58; Cl, 8.86; N, 3.50; O, 8.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
23884-64-2 (cation) 19379-90-9 (chloride)
Synonym
Benzoxonium chloride; D 301; D301; Cohortan; Bialcol; Bradophen;
IUPAC/Chemical Name
Ammonium, benzylbis(2-hydroxyethyl)dodecyl-, chloride
InChi Key
UUSQFLGKGQEVCM-UHFFFAOYSA-M
InChi Code
InChI=1S/C23H42NO2.ClH/c1-2-3-4-5-6-7-8-9-10-14-17-24(18-20-25,19-21-26)22-23-15-12-11-13-16-23;/h11-13,15-16,25-26H,2-10,14,17-22H2,1H3;1H/q+1;/p-1
SMILES Code
CCCCCCCCCCCC[N+](CCO)(CC1=CC=CC=C1)CCO.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Daie Parizi MH, Karvar M, Sharifi I, Bahrampour A, Heshmat Khah A, Rahnama Z, Baziar Z, Amiri R. The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy: a single-blind randomized clinical trial. Dermatol Ther. 2015 May-Jun;28(3):140-6. doi: 10.1111/dth.12229. Epub 2015 Apr 6. PubMed PMID: 25847678. 2: Bruynzeel DP, de Groot AC, Weyland JW. Contact dermatitis to lauryl pyridinium chloride and benzoxonium chloride. Contact Dermatitis. 1987 Jul;17(1):41-2. PubMed PMID: 3652688. 3: Weibel MA, Cortat M, Lebek G, LeCotonnec JY, Kitler ME, Barcherini G. An approach of the in vivo antibacterial activity of benzoxonium chloride and comparison with other buccopharyngeal disinfectants. Arzneimittelforschung. 1987 Apr;37(4):467-71. PubMed PMID: 3606702. 4: Cortat M, Fels P. In vitro activity of benzoxonium chloride on selected buccopharyngeal pathogens. Arzneimittelforschung. 1987 Apr;37(4):463-6. PubMed PMID: 3606701. 5: Finzi GF, Pace M, Grimaldi GP, Perna A, Orlandini L. [Theoretical and experimental considerations on disinfecting substances. Benzoxonium chloride]. Arch Sci Med (Torino). 1982 Jan-Mar;139(1):109-18. Italian. PubMed PMID: 7103699. 6: de Groot AC, Conemans J, Liem DH. Contact allergy to benzoxonium chloride (Bradophen). Contact Dermatitis. 1984 Nov;11(5):324-5. PubMed PMID: 6241131. 7: van Boxtel N, Wolfs K, Palacín MG, Van Schepdael A, Adams E. Headspace gas chromatography based methodology for the analysis of aromatic substituted quaternary ammonium salts. J Chromatogr A. 2016 Dec 9;1476:105-113. doi: 10.1016/j.chroma.2016.11.009. Epub 2016 Nov 9. PubMed PMID: 27884428. 8: Ponzielli G, Taidelli-Palmizi G. [Dodecyl-di-beta-oxyethyl-benzylammonium chloride in the topical therapy of burns]. Clin Ter. 1979 Aug 15;90(3):251-9. Italian. PubMed PMID: 553753. 9: Carpi Torelli P, Tortoli E. [The use of dodecyl-di(beta-oxyethyl) benzylammonium chloride (Bactofen) as a decontaminant in the cultural examination for detection of the Koch bacillus in sputum]. Quad Sclavo Diagn. 1980 Jun;16(2):196-205. Italian. PubMed PMID: 6787655. 10: Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from alkylammonium amidobenzoate. Eur J Dermatol. 2001 May-Jun;11(3):240-3. PubMed PMID: 11358732. 11: Riolo U, Pandiani I, Finzi G. [Behavior of disinfectant substances in comparisons of bacterial strains]. Arch Sci Med (Torino). 1982 Oct-Dec;139(4):499-508. Italian. PubMed PMID: 7168641. 12: Tortoli E. [Preliminary evaluations of the use of dodecyl di-(beta-oxyethyl)-benzylammonium chloride as a routine decontaminant for isolation of mycobacteria]. Quad Sclavo Diagn. 1981 Sep;17(3):277-82. Italian. PubMed PMID: 7343980. 13: Auger RR, Potash JB. Delirium from baclofen withdrawal after suicide attempt. Psychosomatics. 2005 Mar-Apr;46(2):151-2. PubMed PMID: 15774955. 14: Saxer UP, Mörmann W, Firestone AR, Eltink B. Plaque control with chlorhexidine and D-301, a quaternary ammonium compound. J Clin Periodontol. 1982 Mar;9(2):162-9. PubMed PMID: 6951841. 15: Hasmann FA, Pessoa A Jr, Roberto IC. beta-Xylosidase recovery by reversed micelles. Use of cationic surfactant. Appl Biochem Biotechnol. 2000 Spring;84-86:1101-11. PubMed PMID: 10849861. 16: Firestone AR, Schmid R, Mühlemann HR. Topical effects of a quaternary ammonium compound on caries incidence and bacterial agglomerate formation in the rat. Caries Res. 1981;15(4):338-40. PubMed PMID: 6940669. 17: Díaz-Ramón L, Aguirre A, Ratón-Nieto JA, de Miguel M. Contact dermatitis from benzoxonium chloride. Contact Dermatitis. 1999 Jul;41(1):53-4. PubMed PMID: 10416720.