IUPAC/Chemical Name
(+-)-2-(Cyclohexylcarbonyl)-2,3,6,7,8,12b-hexahydropyrazino(2,1-a)(2)benzazepin-4(1H)-one
InChi Key
LGUDKOQUWIHXOV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26N2O2/c23-19-14-21(20(24)16-8-2-1-3-9-16)13-18-17-11-5-4-7-15(17)10-6-12-22(18)19/h4-5,7,11,16,18H,1-3,6,8-10,12-14H2
SMILES Code
O=C1CN(C(C2CCCCC2)=O)CC3C4=CC=CC=C4CCCN31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
326.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zajac AM. Developments in the treatment of gastrointestinal parasites of small animals. Vet Clin North Am Small Anim Pract. 1993 May;23(3):671-81. Review. PubMed PMID: 8503166.
2: Arru E, Garippa G, Manger BR. Efficacy of epsiprantel against Echinococcus granulosus infections in dogs. Res Vet Sci. 1990 Nov;49(3):378-9. PubMed PMID: 2267429.
3: Thompson RC, Reynoldson JA, Manger BR. In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus. Res Vet Sci. 1991 Nov;51(3):332-4. PubMed PMID: 1780591.
4: Białecka W, Kulik A. Determination of active substances in multicomponent veterinary preparations of antiparasitic action by HPLC method. Acta Pol Pharm. 2010 Sep-Oct;67(5):463-8. PubMed PMID: 20873412.
5: Pearce JR, Hendrix CM, Allison N, Butler JM. Macracanthorhynchus ingens infection in a dog. J Am Vet Med Assoc. 2001 Jul 15;219(2):194-6. PubMed PMID: 11469574.
6: Corwin RM, Green SP, Keefe TJ. Dose titration and confirmation tests for determination of cesticidal efficacy of epsiprantel in dogs. Am J Vet Res. 1989 Jul;50(7):1076-7. PubMed PMID: 2774329.
7: Altreuther G, Buch J, Charles SD, Davis WL, Krieger KJ, Radeloff I. Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats. Parasitol Res. 2005 Oct;97 Suppl 1:S58-64. PubMed PMID: 16228276.
8: Eckert J, Thompson RC, Bucklar H, Bilger B, Deplazes P. [Efficacy evaluation of epsiprantel (Cestex) against Echinococcus mutilocularis in dogs and cats]. Berl Munch Tierarztl Wochenschr. 2001 Mar-Apr;114(3-4):121-6. German. PubMed PMID: 11314583.
9: Manger BR, Brewer MD. Epsiprantel, a new tapeworm remedy. Preliminary efficacy studies in dogs and cats. Br Vet J. 1989 Jul-Aug;145(4):384-8. PubMed PMID: 2775987.
10: Brewer MD, Burgess MN, Dorgan RJ, Elliott RL, Mamalis P, Manger BR, Webster RA. Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives. J Med Chem. 1989 Sep;32(9):2058-62. PubMed PMID: 2769679.
