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MedKoo Cat#: 584336 | Name: Paramethasone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Paramethasone is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than Hydrocortisone with supplementary Fludrocortisone.

Chemical Structure

Paramethasone
Paramethasone
CAS#53-33-8

Theoretical Analysis

MedKoo Cat#: 584336

Name: Paramethasone

CAS#: 53-33-8

Chemical Formula: C22H29FO5

Exact Mass: 392.1999

Molecular Weight: 392.47

Elemental Analysis: C, 67.33; H, 7.45; F, 4.84; O, 20.38

Price and Availability

Size Price Availability Quantity
2mg USD 550.00
25mg USD 1,750.00
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Related CAS #
No Data
Synonym
Paramethasone; CS 1483
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
InChi Key
MKPDWECBUAZOHP-AFYJWTTESA-N
InChi Code
InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
SMILES Code
C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Paramethasone is a glucocorticoid with the general properties of corticosteroids.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 392.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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Rheumatology (Oxford). 2012 Aug;51(8):1447-54. doi: 10.1093/rheumatology/kes053. Epub 2012 Mar 30. PMID: 22467087. 5: Bel I, Moreno LA, Gomar C. Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension. Can J Anaesth. 2006 Jun;53(6):591-4. doi: 10.1007/BF03021850. PMID: 16738294. 6: Barriocanal Barriocanal AM, Vaqué Cabañas A, Pérez-Andrés R, Olivé Marques A. Crisis de hipo tras infiltración intraarticular con parametasona [Hiccups crisis following paramethasone intraarticular injection]. Med Clin (Barc). 2005 Jun 25;125(4):158. Spanish. doi: 10.1157/13076947. PMID: 15989860. 7: Ly-Pen D, Andréu JL, de Blas G, Sánchez-Olaso A, Millán I. Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one- year, prospective, randomized, open, controlled clinical trial. Arthritis Rheum. 2005 Feb;52(2):612-9. doi: 10.1002/art.20767. PMID: 15692981. 8: Berthelot JM, Tortellier L, Guillot P, Prost A, Caumon JP, Glemarec J, Maugars Y; SRO (Société de Rhumatologie de l'Ouest). Tachon's syndrome (suracute back and/or thoracic pain following local injections of corticosteroids). A report of 318 French cases. Joint Bone Spine. 2005 Jan;72(1):66-8. doi: 10.1016/j.jbspin.2004.01.005. PMID: 15681251. 9: Kalogirou D, Aroni K, Kalogirou O, Antoniou G, Botsis D, Kontoravdis A. Histological changes induced by tibolone and estrogen/glucocorticoid on aging skin. Int J Fertil Womens Med. 2000 Jul-Aug;45(4):273-8. PMID: 10997483. 10: Ferrando J, Moreno-Arias GA. Multi-injection plate for intralesional corticosteroid treatment of patchy alopecia areata. Dermatol Surg. 2000 Jul;26(7):690-1. doi: 10.1046/j.1524-4725.2000.00002.x. PMID: 10886282. 11: Montoro J, Valero A, Serra-Baldrich E, Amat P, Lluch M, Malet A. Anaphylaxis to paramethasone with tolerance to other corticosteroids. Allergy. 2000 Feb;55(2):197-8. doi: 10.1034/j.1398-9995.2000.00423.x. PMID: 10726740. 12: Galy-Fourcade D, Andrieu V, Sans N, Dromer C, Fournié B, Railhac JJ. Capsulites rétractiles de l'épaule: étude prospective de l'apport de l'imagerie chez 20 patients [Capsular retraction of shoulder: prospective study of imaging benefits in 20 patients]. J Radiol. 2000 Feb;81(2):141-6. French. PMID: 10705144. 13: Andrieu V, Dromer C, Fourcade D, Zabraniecki L, Ginesty E, Marc V, Railhac JJ, Fournié B. Adhesive capsulitis of the shoulder: therapeutic contribution of subacromial bursography. Rev Rhum Engl Ed. 1998 Dec;65(12):771-7. PMID: 9923046. 14: Miranda-Romero A, Bajo-del Pozo C, Sánchez-Sambucety P, Martinez-Fernandez M, Garcia-Muñoz M. Delayed local allergic reaction to intralesional paramethasone acetate. Contact Dermatitis. 1998 Jul;39(1):31-2. doi: 10.1111/j.1600-0536.1998.tb05810.x. PMID: 9686977. 15: Rovira E, García-Escrig M, Catalá J, García J. Aracnoiditis crónica adhesiva tras la administración epidural de parametasona [Chronic adhesive arachnoiditis following epidural paramethasone]. Rev Neurol. 1997 Dec;25(148):2067-8. Spanish. PMID: 9528075. 16: López-Serrano MC, Moreno-Ancillo A, Contreras J, Ortega N, Cabañas R, Barranco P, Muñoz-Pereira M. Two cases of specific adverse reactions to systemic corticosteroids. J Investig Allergol Clin Immunol. 1996 Sep-Oct;6(5):324-7. PMID: 8959545. 17: Cortés-Gallegos V, Villanueva GL, Sojo-Aranda I, Santa Cruz FJ. Inverted skin changes induced by estrogen and estrogen/glucocorticoid on aging dermis. Gynecol Endocrinol. 1996 Apr;10(2):125-8. doi: 10.3109/09513599609097902. PMID: 8701786. 18: Mathelier-Fusade P, Marinho E, Aissaoui M, Mounedji N, Chabane MH, Leynadier F. Toxidermie à la prednisone et prednisolone. Intérêt des tests cutanés dans la recherche de réactions croisées [Toxicoderma caused by prednisone and prednisolone. Value of skin tests in the screening of cross sensitivity]. Ann Dermatol Venereol. 1996;123(8):453-5. French. PMID: 9033713. 19: Gonzalo Garijo MA, Durán Quintana JA, Bobadilla González P, Máiquez Asuero P. Anaphylactic shock following povidone. Ann Pharmacother. 1996 Jan;30(1):37-40. doi: 10.1177/106002809603000107. PMID: 8773164. 20: Valdivieso R, Subiza J, Subiza JL, Narganes MJ, Cabrera M. Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives. J Investig Allergol Clin Immunol. 1995 May-Jun;5(3):171-4. PMID: 7582165.