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MedKoo Cat#: 571497 | Name: Aceclidine free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aceclidine is an agent that treats glaucoma by reducing intraocular pressure.

Chemical Structure

Aceclidine free base
Aceclidine free base
CAS#827-61-2 (free base racemic)

Theoretical Analysis

MedKoo Cat#: 571497

Name: Aceclidine free base

CAS#: 827-61-2 (free base racemic)

Chemical Formula: C9H15NO2

Exact Mass: 169.1103

Molecular Weight: 169.22

Elemental Analysis: C, 63.88; H, 8.93; N, 8.28; O, 18.91

Price and Availability

Size Price Availability Quantity
200mg USD 150.00 2 Weeks
500mg USD 250.00 2 Weeks
1g USD 450.00 2 Weeks
2g USD 750.00 2 Weeks
5g USD 1,450.00 2 Weeks
10g USD 2,250.00 2 Weeks
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Related CAS #
6109-70-2 (HCl racemic) 827-61-2 (free base racemic) 59653-40-6 (R-isomer) 59653-42-8 (S-isomer)
Synonym
Aceclidine; Glaucostat; NSC 657843; NSC-657843; NSC657843
IUPAC/Chemical Name
1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester)
InChi Key
WRJPSSPFHGNBMG-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3
SMILES Code
CC(OC1CN2CCC1CC2)=O
Appearance
liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 169.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ehlert FJ, Griffin MT, Glidden PF. The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor. J Pharmacol Exp Ther. 1996 Dec;279(3):1335-44. PubMed PMID: 8968358. 2: Zhu L, Cui YY, Feng JM, Wu XJ, Chen HZ. Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle. Life Sci. 2006 Feb 28;78(14):1617-23. Epub 2005 Oct 17. PubMed PMID: 16229863. 3: Hubbard WC, Kee C, Kaufman PL. Aceclidine effects on outflow facility after ciliary muscle disinsertion. Ophthalmologica. 1996;210(5):303-7. PubMed PMID: 8878214. 4: Canovetti A, Nardi M, Figus M, Fogagnolo P, Benelli U. Aceclidine, brimonidine tartrate, and dapiprazole: comparison of miotic effect and tolerability under different lighting conditions. J Cataract Refract Surg. 2009 Jan;35(1):42-6. doi: 10.1016/j.jcrs.2008.09.009. PubMed PMID: 19101423. 5: Matera MG, Lampa E, Imperatore A, Berrino L, Russo F, Boldrini E, Rossi F. Bioavailability of timolol and aceclidine after ocular instillation in the rabbit. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):35-42. PubMed PMID: 9644717. 6: Ringdahl B, Ehler FJ, Jenden DJ. Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide. Mol Pharmacol. 1982 May;21(3):594-9. PubMed PMID: 6125875. 7: Gabelt BT, Kaufman PL. Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists. Exp Eye Res. 1994 May;58(5):623-30. PubMed PMID: 7925700. 8: ZAITSEVA KA, MASHKOVSKII MD. [Aceclidine- a new preparation for treatment of postoperative atony of the intestines and urinary bladder]. Med Radiol. 1961 May;5:42-4. Russian. PubMed PMID: 13787701. 9: van der Pol BA, Wattel E. Timolol and aceclidine. A clinical study of interaction in the eye. Acta Ophthalmol (Copenh). 1985 Aug;63(4):411-4. PubMed PMID: 2864775. 10: Keren G, Treister G. Effect of aceclidine(+) isomer and pilocarpine on the intraocular pressure decrease and the miosis in glaucomatous eyes. Effect on accommodation in normal eyes of young subjects. Ophthalmologica. 1980;180(4):181-7. PubMed PMID: 6108545. 11: Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998 Aug;14(4):363-73. PubMed PMID: 9715440. 12: Shumilo TV, Vaĭsman GA. [Chromatographic analysis of aceclidine and oxylidin solutions for injections]. Farm Zh. 1971 Jan-Feb;26(1):74-5. Ukrainian. PubMed PMID: 4396295. 13: Swartz BE, Woody CD, Jenden DJ. The effects of aceclidine, a muscarinic agonist, on neurons in the sensorimotor cortex of awake cats. Proc West Pharmacol Soc. 1978;21:11-7. PubMed PMID: 29300. 14: Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Mitch CH, Whitesitt C, Brunsting D, Sheardown MJ, Olesen PH, Swedberg MD, Jeppesen L, Sauerberg P. 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. J Med Chem. 1998 Jan 29;41(3):379-92. PubMed PMID: 9464368. 15: Uskova NV, Antelava NA. [Comparison of an aceclidine tremor with arecoline and nicotine ones in rats of different ages]. Farmakol Toksikol. 1977 Sep-Oct;40(5):521-4. Russian. PubMed PMID: 21806. 16: Fechner PU, Teichmann KD, Weyrauch W. Accommodative effects of aceclidine in the treatment of glaucoma. Am J Ophthalmol. 1975 Jan;79(1):104-6. PubMed PMID: 1110190. 17: Collignon J, Prijot E. [The effect of a mixture of aceclidine and adrenaline on intraocular pressure of patients showing open-angle glaucoma]. Ophthalmologica. 1970;161(4):394-401. French. PubMed PMID: 5483905. 18: Randazzo A, Nizzola F, Rossetti L, Orzalesi N, Vinciguerra P. Pharmacological management of night vision disturbances after refractive surgery Results of a randomized clinical trial. J Cataract Refract Surg. 2005 Sep;31(9):1764-72. PubMed PMID: 16246781. 19: MASHKOVSKII MD, ZAITSEVA KA. [On the pharmacology of 3-acetoxyquinuclidine (aceclidine)]. Farmakol Toksikol. 1960 Sep-Oct;23:398-406. Russian. PubMed PMID: 13767763. 20: Zabrodskii PF, Lim VG, Shekhter MS, Kuzmin AV. Role of nicotinic and muscarinic cholinoreceptors in the realization of the cholinergic anti-inflammatory pathway during the early phase of sepsis. Bull Exp Biol Med. 2012 Sep;153(5):700-3. PubMed PMID: 23113262.