Synonym
Emepronium bromide; Cetiprin; UNII-WZM699L2TL
IUPAC/Chemical Name
Ammonium, ethyldimethyl(1-methyl-3,3-diphenylpropyl)-, bromide
InChi Key
UVKFSMBPRQBNCH-UHFFFAOYSA-M
InChi Code
InChI=1S/C20H28N.BrH/c1-5-21(3,4)17(2)16-20(18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17,20H,5,16H2,1-4H3;1H/q+1;/p-1
SMILES Code
CC([N+](C)(CC)C)CC(C1=CC=CC=C1)C2=CC=CC=C2.[Br-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
362.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Aagaard J, Reuther K, Stimpel H. A comparison between the combination emepronium bromide/flavoxate and emepronium bromide in the treatment of detrusor instability. Urol Int. 1983;38(3):191-2. doi: 10.1159/000280889. PMID: 6868218.
2: Arcaniolo D, Conquy S, Tarcan T. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31. PMID: 25807422.
3: Pilbrant A, Norlén LJ. Pharmacokinetics and pharmacodynamics of emepronium bromide (Cetiprin) after intravenous administration in man. Acta Pharmacol Toxicol (Copenh). 1985 Apr;56(4):289-97. doi: 10.1111/j.1600-0773.1985.tb01292.x. PMID: 4024956.
4: Brocklehurst JC, Armitage P, Jouhar AJ. Emepronium bromide in urinary incontinence. Age Ageing. 1972 Aug;1(3):152-7. doi: 10.1093/ageing/1.3.152. PMID: 4593683.
5: Andersen JR, Lose G, Nørgaard M, Stimpel H, Andersen JT. Terodiline, emepronium bromide or placebo for treatment of female detrusor overactivity? A randomised, double-blind, cross-over study. Br J Urol. 1988 Apr;61(4):310-3. doi: 10.1111/j.1464-410x.1988.tb13964.x. PMID: 3289675.
6: Wall LL. The management of detrusor instability. Clin Obstet Gynecol. 1990 Jun;33(2):367-77. doi: 10.1097/00003081-199006000-00021. PMID: 2190740.
7: Obrink A, Bunne G. Treatment of urgency by instillation of emepronium bromide in the urinary bladder. Scand J Urol Nephrol. 1978;12(3):215-8. doi: 10.3109/00365597809179719. PMID: 364631.
8: Zografos GN, Georgiadou D, Thomas D, Kaltsas G, Digalakis M. Drug-induced esophagitis. Dis Esophagus. 2009;22(8):633-7. doi: 10.1111/j.1442-2050.2009.00972.x. Epub 2009 Apr 15. PMID: 19392845.
9: Robinson JM, Brocklehurst JC. Emepronium bromide and flavoxate hydrochloride in the treatment of urinary incontinence associated with detrusor instability in elderly women. Br J Urol. 1983 Aug;55(4):371-6. doi: 10.1111/j.1464-410x.1983.tb03325.x. PMID: 6349743.
10: Hallén B, Sundwall A, Sandquist S. Ion pair formation and gastrointestinal absorption of emepronium. Acta Pharmacol Toxicol (Copenh). 1985 Oct;57(4):271-8. doi: 10.1111/j.1600-0773.1985.tb00042.x. PMID: 4083035.
