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MedKoo Cat#: 597049 | Name: Erythritol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Erythritol is a four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator.

Chemical Structure

Erythritol
Erythritol
CAS#149-32-6

Theoretical Analysis

MedKoo Cat#: 597049

Name: Erythritol

CAS#: 149-32-6

Chemical Formula: C4H10O4

Exact Mass: 122.0579

Molecular Weight: 122.12

Elemental Analysis: C, 39.34; H, 8.25; O, 52.40

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
25g USD 450.00 2 weeks
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Related CAS #
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Synonym
Erythritol; L-Erythritol; Phycitol; Mesoerythritol; meso-Erythritol; Erythrit; NSC 8099; NSC-8099; NSC8099;
IUPAC/Chemical Name
(2R,3S)-Butane-1,2,3,4-tetraol
InChi Key
UNXHWFMMPAWVPI-ZXZARUISSA-N
InChi Code
InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4+
SMILES Code
OC[C@@H](O)[C@@H](O)CO
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80% as sweet as sucrose, and is an approved low-calorie sweetener food additive.
In vitro activity:
TBD
In vivo activity:
From the age of 11 weeks, the body weight of mice fed an HFD and erythritol (Ery group) were significantly lower than those of mice fed an HFD (Ctrl group) (Figure 1A). In contrast, the cumulative oral intake and water consumption did not significantly differ between both groups (Figure 1B,C). In the iPGTT and ITT, the AUCs of blood glucose in the Ery group were significantly lower than those in the Ctrl group (p < 0.001 for both; Figure 1D–G). Reference: Int J Mol Sci. 2021 Jun; 22(11): 5558. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197374/
Solvent mg/mL mM
Solubility
DMSO 24.0 196.53
Water 24.0 196.53
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 122.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kawano R, Okamura T, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Asano M, Yamazaki M, Takakuwa H, Sasano R, Nakanishi N, Hamaguchi M, Fukui M. Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance. Int J Mol Sci. 2021 May 24;22(11):5558. doi: 10.3390/ijms22115558. PMID: 34074061; PMCID: PMC8197374. 2. Wen H, Tang B, Stewart AJ, Tao Y, Shao Y, Cui Y, Yue H, Pei J, Liu Z, Mei L, Yu R, Jiang L. Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase. J Agric Food Chem. 2018 Feb 14;66(6):1401-1407. doi: 10.1021/acs.jafc.7b05033. Epub 2018 Feb 5. PMID: 29361825.
In vitro protocol:
TBD
In vivo protocol:
1. Kawano R, Okamura T, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Asano M, Yamazaki M, Takakuwa H, Sasano R, Nakanishi N, Hamaguchi M, Fukui M. Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance. Int J Mol Sci. 2021 May 24;22(11):5558. doi: 10.3390/ijms22115558. PMID: 34074061; PMCID: PMC8197374. 2. Wen H, Tang B, Stewart AJ, Tao Y, Shao Y, Cui Y, Yue H, Pei J, Liu Z, Mei L, Yu R, Jiang L. Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase. J Agric Food Chem. 2018 Feb 14;66(6):1401-1407. doi: 10.1021/acs.jafc.7b05033. Epub 2018 Feb 5. PMID: 29361825.
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Structural modeling identifies Plasmodium vivax 4-diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) as a plausible new antimalarial drug target. Parasitol Int. 2018 Aug;67(4):375-385. doi: 10.1016/j.parint.2018.03.001. Epub 2018 Mar 14. PubMed PMID: 29550587. 17: Contreras A, Ribbeck M, Gutiérrez GD, Cañon PM, Mendoza SN, Agosin E. Mapping the Physiological Response of Oenococcus oeni to Ethanol Stress Using an Extended Genome-Scale Metabolic Model. Front Microbiol. 2018 Mar 1;9:291. doi: 10.3389/fmicb.2018.00291. eCollection 2018. PubMed PMID: 29545779; PubMed Central PMCID: PMC5838312. 18: Myers EA, Passaro EM, Hedrick VE. The Comparative Reproducibility and Validity of a Non-Nutritive Sweetener Food Frequency Questionnaire. Nutrients. 2018 Mar 10;10(3). pii: E334. doi: 10.3390/nu10030334. PubMed PMID: 29534454; PubMed Central PMCID: PMC5872752. 19: Conde A, Neves A, Breia R, Pimentel D, Dinis LT, Bernardo S, Correia CM, Cunha A, Gerós H, Moutinho-Pereira J. 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