Synonym
P18IN 011; P18IN-011; P18IN011;
IUPAC/Chemical Name
1,2-Benzoxazol-3-yl 4-acetamidobenzenesulfonate
InChi Key
SIXNKGXJEIVCDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12N2O5S/c1-10(18)16-11-6-8-12(9-7-11)23(19,20)22-15-13-4-2-3-5-14(13)21-17-15/h2-9H,1H3,(H,16,18)
SMILES Code
O=S(C1=CC=C(NC(C)=O)C=C1)(OC2=NOC3=CC=CC=C23)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
P18IN011 is a novel p18(INK4C) inhibitor.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Lefkowitz RJ. Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. Biochem Pharmacol. 1975 Sep 15;24(18):1651-8. PubMed PMID: 11.
2: Gao, Y., Yang, P., Shen, H., Yu, H., Song, X., Zhang, L., ... & Xie, X. Q. (2015). Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells. Nature communications, 6(1), 6328.
3: Zhang, Y., & Gao, Y. (2016). Novel chemical attempts at ex vivo hematopoietic stem cell expansion. International journal of hematology, 103(5), 519-529.
