B355252 | CAS#1261576-81-1

MedKoo Cat#: 341187 | Name: B355252

Description:

WARNING: This product is for research use only, not for human or veterinary use.

B355252 is a neuroprotective agent that potentiates nerve growth factor (NGF)-induced neurite outgrowth and protects against cell death caused by glutamate-evoked oxidative stress.

Chemical Structure

B355252

CAS#1261576-81-1

Theoretical Analysis

MedKoo Cat#: 341187

Name: B355252

CAS#: 1261576-81-1

Chemical Formula: C25H24ClN3O3S2

Exact Mass: 513.0948

Molecular Weight: 514.06

Elemental Analysis: C, 58.41; H, 4.71; Cl, 6.90; N, 8.17; O, 9.34; S, 12.47

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
1g	USD 4,250.00	2 Weeks

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Related CAS #

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Synonym

B355252; B 355252; B-355252.

IUPAC/Chemical Name

4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

InChi Key

YAAVQYDOVJQDFZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H24ClN3O3S2/c26-23-16-24(34(30,31)28-17-19-7-3-6-18-5-1-2-10-22(18)19)33-25(23)32-21-9-4-8-20(15-21)29-13-11-27-12-14-29/h1-10,15-16,27-28H,11-14,17H2

SMILES Code

O=S(C1=CC(Cl)=C(OC2=CC=CC(N3CCNCC3)=C2)S1)(NCC4=C5C=CC=CC5=CC=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

B355252 is a neuroprotective agent potentiating nerve growth factor (NGF)-induced neurite outgrowth.

In vitro activity:

B355252 protected HT22 neurons against 6-OHDA toxin-induced neuronal cell death by significant attenuation of ROS production, blocking of mitochondrial depolarization, inhibition of cytochrome c release, sequestration of [Ca(2+)]i, modulation of JNK cascade, and strong inhibition of caspase 3/7 cleavage. Overall, the data demonstrates that death of neurons under toxic conditions characteristic of Parkinson’s Disease can be efficiently halted by B355252. Reference: Cell Mol Neurobiol. 2016 Oct;36(7):1109-22. https://link.springer.com/article/10.1007/s10571-015-0304-5

In vivo activity:

B355252 protected ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. Moreover, inflammatory responses in astrocytic and microglial gliosis, as well as IL-1β and TNF-α levels, were ameliorated. Consequently, the behavioral outcomes of ischemic rats in neurologic responses and fore paw function recovery were improved. Reference: J Inflamm Res. 2021 Jun 1;14:2363-2376. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179829/

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	58.36
	DMSO	30.0	58.36
	DMSO:PBS (pH 7.2) (1:4)	0.2	0.39

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 514.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Chimeh U, Zimmerman MA, Gilyazova N, Li PA. B355252, A Novel Small Molecule, Confers Neuroprotection Against Cobalt Chloride Toxicity In Mouse Hippocampal Cells Through Altering Mitochondrial Dynamics And Limiting Autophagy Induction. Int J Med Sci. 2018 Sep 7;15(12):1384-1396. doi: 10.7150/ijms.24702. PMID: 30275767; PMCID: PMC6158673. 2. Gliyazova NS, Ibeanu GC. The Chemical Molecule B355252 is Neuroprotective in an In Vitro Model of Parkinson's Disease. Cell Mol Neurobiol. 2016 Oct;36(7):1109-22. doi: 10.1007/s10571-015-0304-5. Epub 2015 Dec 9. PMID: 26649727. 3. Wang HK, Chen JS, Hsu CY, Su YT, Sung TC, Liang CL, Kwan AL, Wu CC. A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia. J Inflamm Res. 2021 Jun 1;14:2363-2376. doi: 10.2147/JIR.S303833. PMID: 34103967; PMCID: PMC8179829.

In vitro protocol:

In vivo protocol:

1. Wang HK, Chen JS, Hsu CY, Su YT, Sung TC, Liang CL, Kwan AL, Wu CC. A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia. J Inflamm Res. 2021 Jun 1;14:2363-2376. doi: 10.2147/JIR.S303833. PMID: 34103967; PMCID: PMC8179829.

1: Gliyazova NS, Ibeanu GC. The Chemical Molecule B355252 is Neuroprotective in an In Vitro Model of Parkinson's Disease. Cell Mol Neurobiol. 2016 Oct;36(7):1109-22. doi: 10.1007/s10571-015-0304-5. Epub 2015 Dec 9. PubMed PMID: 26649727. 2: Gliyazova NS, Huh EY, Ibeanu GC. A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model. BMC Neurosci. 2013 Sep 2;14:93. doi: 10.1186/1471-2202-14-93. PubMed PMID: 24004478; PubMed Central PMCID: PMC3846642.