K137 | CAS#1298095-31-4 | CK2 inhibitor

MedKoo Cat#: 533271 | Name: K137

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K137 is a potent and competitive CK2 inhibitor.

Chemical Structure

K137

CAS#1298095-31-4

Theoretical Analysis

MedKoo Cat#: 533271

Name: K137

CAS#: 1298095-31-4

Chemical Formula: C10H10Br4N4

Exact Mass: 501.7639

Molecular Weight: 505.83

Elemental Analysis: C, 23.74; H, 1.99; Br, 63.19; N, 11.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

K137; K-137; K 137

IUPAC/Chemical Name

N1-(4,5,6,7-Tetrabromo-1H-benzimidazol-2-yl)-propane-1,3-diamine

InChi Key

XOTCJGHQJDBEEH-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H10Br4N4/c11-4-5(12)7(14)9-8(6(4)13)17-10(18-9)16-3-1-2-15/h1-3,15H2,(H2,16,17,18)

SMILES Code

NCCCNC1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Casein kinase II (CK2) is an ubiquitous and pleiotropic serine/threonine protein kinase able to phosphorylate hundreds of substrates. Being implicated in several human diseases, from neurodegeneration to cancer, the biological roles of CK2 have been intensively studied. Upregulation of CK2 has been shown to be critical to tumor progression, making this kinase an attractive target for cancer therapy.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 505.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Cozza G, Zanin S, Sarno S, Costa E, Girardi C, Ribaudo G, Salvi M, Zagotto G, Ruzzene M, Pinna LA. Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity. Biochem J. 2015 Nov 1;471(3):415-30. doi: 10.1042/BJ20141127. Epub 2015 Sep 8. PMID: 26349539.